EFFECT OF COENZYME Q10 SUPPLEMENTATION ON DIABETES BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

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MORADI MAEDEH; HAGHIGHATDOOST FAHIMEH; FEIZI AWAT; AZADBAKHT LEILA

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2016 | Volume:19 | Issue:8 Page(s): 588-596

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Title

EFFECT OF COENZYME Q10 SUPPLEMENTATION ON DIABETES BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS

Author(s)

MORADI MAEDEH | HAGHIGHATDOOST FAHIMEH | FEIZI AWAT | AZADBAKHT LEILA | Issue Writer Certificate

Keywords

CO-Q10

FASTING BLOOD GLUCOSE

FASTING INSULIN

GLYCEMIC CONTROL

HBA1C DIABETES MELLITUS

Abstract

BACKGROUND: Several studies have investigated the effect of CO-Q10 on diabetes biomarkers, but findings are inconsistent. This systematic review and meta-analysis of clinical trials was conducted to summarize the effect of CO-Q10 supplementation on diabetes biomarkers.METHODS: We searched Pubmed, EMBASE, Science direct, ISI web of science, and Google Scholar for randomized controlled trials from 1989 until March 2016. We included randomized controlled trials reporting FASTING BLOOD GLUCOSE (FBG), FASTING INSULIN and HbA1c. In total, we found 16 articles that examined the effect of CO-Q10 on FASTING BLOOD GLUCOSE, FASTING INSULIN and HbA1c. Mean ± standard deviations (SD) of defined outcomes were used for calculating standardized mean differences (SMD) and its 95% confidence interval (95%CI) between intervention and control treatments based on Hedges’ estimator. RESULTS: Our preliminary meta-analysis on 14 eligible studies regarding the effect of CO-Q10 supplementation on FBG indicated a slightly significant decrement (SMD:-0.28 mg/d; 95% CI: -0.12, 0.04), with a substantial between-study heterogeneity (Cochrane Q test, I2=93.9%, P<0.0001). After removal of three studies, heterogeneity was eliminated and a slightly significant decrease was found in FBG (SMD: -0.20 mg/dL, 95% CI: -0.38, -0.02). The effect of CO-Q10 on HbA1c and FASTING INSULIN was not significant. SMDs for the effect of CO-Q10 on HbA1c and FASTING INSULIN were -0.05% (95% CI: -0.22, 0.12) and 0.12 pmol/L (95% CI: -0.21, 0.44), respectively. CONCLUSION: CO-Q10 supplementation slightly but significantly reduced FASTING BLOOD GLUCOSE, but not FASTING INSULIN and HbA1c. More long-term studies are necessary to examine the association between CO-Q10 supplementation and diabetes biomarkers.This study was funded by the School of Nutrition and Food Science, Isfahan University of Medical Sciences.

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APA: Copy

MORADI, MAEDEH, HAGHIGHATDOOST, FAHIMEH, FEIZI, AWAT, & AZADBAKHT, LEILA. (2016). EFFECT OF COENZYME Q10 SUPPLEMENTATION ON DIABETES BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS. ARCHIVES OF IRANIAN MEDICINE, 19(8), 588-596. SID. https://sid.ir/paper/281355/en

Vancouver: Copy

MORADI MAEDEH, HAGHIGHATDOOST FAHIMEH, FEIZI AWAT, AZADBAKHT LEILA. EFFECT OF COENZYME Q10 SUPPLEMENTATION ON DIABETES BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(8):588-596. Available from: https://sid.ir/paper/281355/en

IEEE: Copy

MAEDEH MORADI, FAHIMEH HAGHIGHATDOOST, AWAT FEIZI, and LEILA AZADBAKHT, “EFFECT OF COENZYME Q10 SUPPLEMENTATION ON DIABETES BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED CLINICAL TRIALS,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 8, pp. 588–596, 2016, [Online]. Available: https://sid.ir/paper/281355/en

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