Increased Serum Pepsinogen II Level as a Marker of Pangastritis and Corpus-Predominant Gastritis in Gastric Cancer Prevention

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MASSARRAT SADEGH; HAJ SHEYKHOLESLAMI ARGHAVAN

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2016 | Volume:19 | Issue:2 Page(s): 137-140

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Title

Increased Serum Pepsinogen II Level as a Marker of Pangastritis and Corpus-Predominant Gastritis in Gastric Cancer Prevention

Author(s)

MASSARRAT SADEGH | HAJ SHEYKHOLESLAMI ARGHAVAN | Issue Writer Certificate

Keywords

Gastric cancer prevention

serum pepsinogen II

Abstract

Serum pepsinogen I and II are considered as indicators of changes in gastric morphology. Important publications from the last decades are reviewed with regard to the serum level of these biomarkers for the diagnosis of normal gastric mucosa, diffuse gastritis and its change to atrophic gastritis and intestinal metaplasia as well as gastric cancer. Due to the low sensitivity of serum biomarkers for diagnosis of gastric cancer, especially at its early stage and the poor prognosis of the tumor at the time of diagnosis, its prevention by eradication of H. pylori remains the mandatory strategy. On the other hand, the severity of regression and non-reversibility of precancerous lesions and intestinal metaplasia in gastric mucosa through eradication of H. pylori make it necessary to diagnose diffuse gastritis at its early stage. Increased serum pepsinogen II compared to normal serum pepsinogen I seems to indicate the presence of diffuse gastritis without precancerous lesions suitable for eradication of H. pylori infection, when it is serologically positive. A diagram illustrates the strategy of this therapeutic measure depending on the age of people and the level of serum biomarkers in areas with high gastric cancer prevalence.

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APA: Copy

MASSARRAT, SADEGH, & HAJ SHEYKHOLESLAMI, ARGHAVAN. (2016). Increased Serum Pepsinogen II Level as a Marker of Pangastritis and Corpus-Predominant Gastritis in Gastric Cancer Prevention. ARCHIVES OF IRANIAN MEDICINE, 19(2), 137-140. SID. https://sid.ir/paper/281439/en

Vancouver: Copy

MASSARRAT SADEGH, HAJ SHEYKHOLESLAMI ARGHAVAN. Increased Serum Pepsinogen II Level as a Marker of Pangastritis and Corpus-Predominant Gastritis in Gastric Cancer Prevention. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(2):137-140. Available from: https://sid.ir/paper/281439/en

IEEE: Copy

SADEGH MASSARRAT, and ARGHAVAN HAJ SHEYKHOLESLAMI, “Increased Serum Pepsinogen II Level as a Marker of Pangastritis and Corpus-Predominant Gastritis in Gastric Cancer Prevention,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 2, pp. 137–140, 2016, [Online]. Available: https://sid.ir/paper/281439/en

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