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Information Journal Paper

Title

Correlation between Heart, Liver and Pancreas Hemosiderosis Measured by MRI T2* among Thalassemia Major Patients from Iran

Pages

  96-100

Abstract

 INTRODUCTION: Major thalassemic patients need lifelong transfusions. The consequence of these repeated transfusions is iron accumulation in different organs. The main aim of the present study was to investigate the correlation between heart, liver and pancreas Hemosiderosis in thalassemic patients from Iran. METHODS: This cross-sectional study was conducted on 164 major thalassemia patients at Zafar Adult thalassemia Center, a referral thalassemia center in Tehran, Iran, from May to November 2014. All patients were on regular blood transfusion at 2– 4 week intervals to keep their hemoglobin at a level of 7– 9 gr/dL before each transfusion. Demographic data were gathered from patients’ history. MRI T2** of liver, heart and pancreas were performed for all patients. RESULTS: There was a moderate correlation between pancreatic T2* and cardiac T2* relaxation times (r = 0. 42, P < 0. 001), a weak to moderate correlation between T2* of pancreas and liver (r = 0. 41, P < 0. 001), and a weak correlation between T2* relaxation times of heart and liver (r = 0. 31, P < 0. 001). CONCLUSION: Poor correlation between liver and heart, as well as a weak to moderate correlation between pancreas and liver T2* relaxation times indicate that relying on liver MRI T2** to predict the exact condition of pancreas or heart iron overload might not be a reliable approach in thalassemia major patients. Our findings suggest the advantage of using pancreas and heart MRI T2** as a non-invasive method for estimation of iron overload instead of relying on liver MRI T2**.

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    APA: Copy

    AZARKEIVAN, AZITA, HASHEMIEH, MOZHGAN, SHIRKAVAND, AFSHAN, & SHEIBANI, KOUROSH. (2016). Correlation between Heart, Liver and Pancreas Hemosiderosis Measured by MRI T2* among Thalassemia Major Patients from Iran. ARCHIVES OF IRANIAN MEDICINE, 19(2), 96-100. SID. https://sid.ir/paper/281447/en

    Vancouver: Copy

    AZARKEIVAN AZITA, HASHEMIEH MOZHGAN, SHIRKAVAND AFSHAN, SHEIBANI KOUROSH. Correlation between Heart, Liver and Pancreas Hemosiderosis Measured by MRI T2* among Thalassemia Major Patients from Iran. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(2):96-100. Available from: https://sid.ir/paper/281447/en

    IEEE: Copy

    AZITA AZARKEIVAN, MOZHGAN HASHEMIEH, AFSHAN SHIRKAVAND, and KOUROSH SHEIBANI, “Correlation between Heart, Liver and Pancreas Hemosiderosis Measured by MRI T2* among Thalassemia Major Patients from Iran,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 2, pp. 96–100, 2016, [Online]. Available: https://sid.ir/paper/281447/en

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