THE PREVALENCE OF PCR-CONFIRMED PERTUSSIS CASES IN PALESTINE FROM ARCHIVED NASOPHARYNGEAL SAMPLES

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DUMAIDI KAMAL; AL JAWABREH AMER

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Journal Paper

Paper Information

Journal: ARCHIVES OF IRANIAN MEDICINE Year:2018 | Volume:21 | Issue:5 Page(s): 208-212

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Title

THE PREVALENCE OF PCR-CONFIRMED PERTUSSIS CASES IN PALESTINE FROM ARCHIVED NASOPHARYNGEAL SAMPLES

Author(s)

DUMAIDI KAMAL | AL JAWABREH AMER | Issue Writer Certificate

Keywords

ACELLULAR PERTUSSIS VACCINE (AP)

BORDETELLA PERTUSSIS

PALESTINE

PCR

PERTUSSIS VACCINE

WHOLE-CELL PERTUSSIS VACCINE (WP)

Abstract

Background: Pertussis caused by BORDETELLA PERTUSSIS is a vaccine-preventable disease causing whooping cough in humans of all ages. This study reports infection rate of pertussis in PALESTINE between the years 2004-2008 from archived nasopharyngeal samples collected from clinically-suspected cases. Methods: A convenience archived DNA samples collected from 267 clinically-suspected pertussis cases were investigated for B. pertussis. Laboratory diagnosis was done by examining all DNA samples using polymerase chain reaction (PCR). Results: Approximately 49% (130/267) were confirmed by PCR. A pertussis peak was shown to occur in 2008 with 77% (100/130) of PCR-confirmed cases isolated in that year. PCR-confirmed cases existed in all Palestinian districts with highest rate in Ramallah, Bethlehem, Jenin and Al-Khalil. Half of the PCR-confirmed cases (68/130) were less than 2 months old. The positivity rate among who had three doses of vaccine (at 2, 4 and 6 months) was 38%, and became 50% with the fourth dose at 12 months. Conclusion: The prevalence of pertussis was found to be significantly high among infants less than 2 months old. Active pertussis surveillance using rapid PCR assays is essential, as it is helpful in prompt diagnosis and treatment of patients with pertussis.

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APA: Copy

DUMAIDI, KAMAL, & AL JAWABREH, AMER. (2018). THE PREVALENCE OF PCR-CONFIRMED PERTUSSIS CASES IN PALESTINE FROM ARCHIVED NASOPHARYNGEAL SAMPLES. ARCHIVES OF IRANIAN MEDICINE, 21(5), 208-212. SID. https://sid.ir/paper/281526/en

Vancouver: Copy

DUMAIDI KAMAL, AL JAWABREH AMER. THE PREVALENCE OF PCR-CONFIRMED PERTUSSIS CASES IN PALESTINE FROM ARCHIVED NASOPHARYNGEAL SAMPLES. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(5):208-212. Available from: https://sid.ir/paper/281526/en

IEEE: Copy

KAMAL DUMAIDI, and AMER AL JAWABREH, “THE PREVALENCE OF PCR-CONFIRMED PERTUSSIS CASES IN PALESTINE FROM ARCHIVED NASOPHARYNGEAL SAMPLES,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 5, pp. 208–212, 2018, [Online]. Available: https://sid.ir/paper/281526/en

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