مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

MUTATIONS IN KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN YOUNG PATIENTS WITH PANCREATIC CANCER

Pages

  228-233

Abstract

 Background: PANCREATIC CANCER is the fourth most common cause of mortality due to cancer, globally. It has a poor prognosis and is usually diagnosed at later stages when tumor resection is not possible. Heritability for PANCREATIC CANCER is relatively high and clinically significant. Methods: A group of 24 PANCREATIC CANCER patients with young age at onset, from a referral hospital in Tehran University of Medical Sciences were screened for mutations in 710 cancer relevant genes using next generation sequencing technology. Results: Two patients had pathogenic mutations in known PANCREATIC CANCER SUSCEPTIBILITY GENES, BRCA1/2. Two other patients also had potentially pathogenic mutations in 2 novel candidate genes including PARP4 and EXO1. Conclusion: BRCA1/2 genes are the most commonly mutated PANCREATIC CANCER SUSCEPTIBILITY GENES that should be considered in all PANCREATIC CANCER cases with young age at onset or a family history of cancer. PARP4 and EXO1 also are potential candidate genes for susceptibility to PANCREATIC CANCER. Identifying the HEREDITARY cases of PANCREATIC CANCER will help to offer more targeted treatments to the patients and also to prevent cancer in family members who might be a mutation carrier.

Cites

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    • Cite

    APA: Copy

    ALIMIRZAIE, SAHAR, MOHAMADKHANI, ASHRAF, MASOUDI, SAHAR, SELLARS, ERIN, BOFFETTA, PAOLO, MALEKZADEH, REZA, AKBARI, MOHAMMAD R., & POURSHAMS, AKRAM. (2018). MUTATIONS IN KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN YOUNG PATIENTS WITH PANCREATIC CANCER. ARCHIVES OF IRANIAN MEDICINE, 21(6), 228-233. SID. https://sid.ir/paper/281535/en

    Vancouver: Copy

    ALIMIRZAIE SAHAR, MOHAMADKHANI ASHRAF, MASOUDI SAHAR, SELLARS ERIN, BOFFETTA PAOLO, MALEKZADEH REZA, AKBARI MOHAMMAD R., POURSHAMS AKRAM. MUTATIONS IN KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN YOUNG PATIENTS WITH PANCREATIC CANCER. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2018;21(6):228-233. Available from: https://sid.ir/paper/281535/en

    IEEE: Copy

    SAHAR ALIMIRZAIE, ASHRAF MOHAMADKHANI, SAHAR MASOUDI, ERIN SELLARS, PAOLO BOFFETTA, REZA MALEKZADEH, MOHAMMAD R. AKBARI, and AKRAM POURSHAMS, “MUTATIONS IN KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN YOUNG PATIENTS WITH PANCREATIC CANCER,” ARCHIVES OF IRANIAN MEDICINE, vol. 21, no. 6, pp. 228–233, 2018, [Online]. Available: https://sid.ir/paper/281535/en

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