POTENTIAL CORRELATION BETWEEN CIRCULATING FETUIN-A AND PENTRAXIN-3 WITH BIOCHEMICAL PARAMETERS OF CALCIFICATION IN HEMODIALYSIS PATIENTS (BRIEF REPORT)

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HASHEMI JAVAD; JOSHAGHANI HAMIDREZA; AKABERI ARASH; HESARI ZAHRA; GHANBARI REZA; MOHAMMADZADEH MOHSEN; GOLSHAN ALIREZA

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2017 | Volume:20 | Issue:12 Page(s): 752-755

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Title

POTENTIAL CORRELATION BETWEEN CIRCULATING FETUIN-A AND PENTRAXIN-3 WITH BIOCHEMICAL PARAMETERS OF CALCIFICATION IN HEMODIALYSIS PATIENTS (BRIEF REPORT)

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Keywords

FETUIN-A

HEMODIALYSIS PATIENTS

PENTRAXIN-3

Abstract

Background: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. FETUIN-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between FETUIN-A and PTX3with some biochemical parameters effective upon vascular calcification in HD patients. Methods: We included 84 HD patients and 84 healthy controls matched for age, gender, and body mass index (BMI) in this study. Blood samples were drawn from all subjects and the serum levels of creatinine, urea, albumin, calcium (Ca), phosphorus (P), low-density lipoprotein cholesterol (LDL-C), parathyroid hormone, FETUIN-A, high sensitive C-reactive protein, and PTX3were measured by biochemical methods. Results: We found that the serum levels of PTX3, C-reactive protein (CRP), parathyroid hormone (PTH), Ca, and P in the patient group were significantly higher than the control group but the serum levels of FETUIN-A and albumin were significantly lower in the patient group. Also, FETUIN-A had a significant correlation with high sensitive CRP (hs-CRP) as well as duration of dialysis. In addition, it was shown that the correlation between PTX3 and PTH was significant only in the patient group. Conclusion: In this study, increased PTX3 and decreased FETUIN-A levels were observed in the HD patients. According to our results, these 2 parameters may potentially serve as suitable markers for inflammation and prediction of vascular complications in these patients.

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APA: Copy

HASHEMI, JAVAD, JOSHAGHANI, HAMIDREZA, AKABERI, ARASH, HESARI, ZAHRA, GHANBARI, REZA, MOHAMMADZADEH, MOHSEN, & GOLSHAN, ALIREZA. (2017). POTENTIAL CORRELATION BETWEEN CIRCULATING FETUIN-A AND PENTRAXIN-3 WITH BIOCHEMICAL PARAMETERS OF CALCIFICATION IN HEMODIALYSIS PATIENTS (BRIEF REPORT). ARCHIVES OF IRANIAN MEDICINE, 20(12), 752-755. SID. https://sid.ir/paper/281604/en

Vancouver: Copy

HASHEMI JAVAD, JOSHAGHANI HAMIDREZA, AKABERI ARASH, HESARI ZAHRA, GHANBARI REZA, MOHAMMADZADEH MOHSEN, GOLSHAN ALIREZA. POTENTIAL CORRELATION BETWEEN CIRCULATING FETUIN-A AND PENTRAXIN-3 WITH BIOCHEMICAL PARAMETERS OF CALCIFICATION IN HEMODIALYSIS PATIENTS (BRIEF REPORT). ARCHIVES OF IRANIAN MEDICINE[Internet]. 2017;20(12):752-755. Available from: https://sid.ir/paper/281604/en

IEEE: Copy

JAVAD HASHEMI, HAMIDREZA JOSHAGHANI, ARASH AKABERI, ZAHRA HESARI, REZA GHANBARI, MOHSEN MOHAMMADZADEH, and ALIREZA GOLSHAN, “POTENTIAL CORRELATION BETWEEN CIRCULATING FETUIN-A AND PENTRAXIN-3 WITH BIOCHEMICAL PARAMETERS OF CALCIFICATION IN HEMODIALYSIS PATIENTS (BRIEF REPORT),” ARCHIVES OF IRANIAN MEDICINE, vol. 20, no. 12, pp. 752–755, 2017, [Online]. Available: https://sid.ir/paper/281604/en

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