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Information Journal Paper

Title

Study of Transected Sciatic Nerve Repair by Amniotic Membrane with Betamethasone in Adult Albino Wistar Rats

Pages

  612-617

Abstract

 Background: The aim of this study was to determine the effects of Amniotic membrane impregnated with betamethasone on regeneration of transected sciatic nerve injury in adult albino Wister rats. Methods: In this research, 42 male adult rats were divided into six equal groups. 1) Normal (intact) group: healthy rats without any injury; 2) Control group: sciatic nerve was cut and sutured; 3) Sham group: 0. 2 mL culture medium was injected on the epineurium in the injury; 4) Amniotic membrane group (AM): Acellular Amniotic membrane was used around the damaged sciatic nerve; 5) betamethasone group (B): 0. 2 mL betamethasone (4 mg/mL) was injected in the site of damaged nerve and 6) Amniotic membrane group and betamethasone (AM/B) group: Acellular Amniotic membrane impregnated with 0. 2 mL betamethasone was used around the damaged sciatic nerve. The rate of recovery was studied by Sciatic Functional Index (SFI), withdrawal 􀁕 􀁈 􀃀 􀁈 􀁛 latency (WRL) test and electroctrophysiological assessments at 2, 4, 6 and 8 weeks after surgery. Histological assessment was done 8 weeks after surgery. Results: At 8 weeks after surgery, SFI, WRL test and electrophysiological values in AM/B group were 􀁖 􀁌 􀁊 􀁑 􀁌 􀂿 􀁆 􀁄 􀁑 􀁗 􀁏 􀁜 improved compared to control and sham groups (P < 0. 05). Histological results showed improvement in therapeutic groups, especially AM/B group compared to control and sham groups and other therapeutic groups (P < 0. 05). Conclusion: The present study showed the positive effects of Amniotic membrane and betamethasone on nerve regeneration of transected sciatic nerve in a rat model.

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    APA: Copy

    SADRAIE, SEYED HOMAYOON, PARIVAR, KAZEM, Arabi, Farzaneh, MOATTARI, MEHRNAZ, KAKA, GHOLAMREZA, & MANSOURI, KOROSH. (2016). Study of Transected Sciatic Nerve Repair by Amniotic Membrane with Betamethasone in Adult Albino Wistar Rats. ARCHIVES OF IRANIAN MEDICINE, 19(9), 612-617. SID. https://sid.ir/paper/281717/en

    Vancouver: Copy

    SADRAIE SEYED HOMAYOON, PARIVAR KAZEM, Arabi Farzaneh, MOATTARI MEHRNAZ, KAKA GHOLAMREZA, MANSOURI KOROSH. Study of Transected Sciatic Nerve Repair by Amniotic Membrane with Betamethasone in Adult Albino Wistar Rats. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(9):612-617. Available from: https://sid.ir/paper/281717/en

    IEEE: Copy

    SEYED HOMAYOON SADRAIE, KAZEM PARIVAR, Farzaneh Arabi, MEHRNAZ MOATTARI, GHOLAMREZA KAKA, and KOROSH MANSOURI, “Study of Transected Sciatic Nerve Repair by Amniotic Membrane with Betamethasone in Adult Albino Wistar Rats,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 9, pp. 612–617, 2016, [Online]. Available: https://sid.ir/paper/281717/en

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