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Information Journal Paper

Title

Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells

Pages

  23-29

Abstract

 BACKGROUND: sodium selenite and ginsenoside Rh2 (G-Rh2) are well known for their anticancer properties and have been exploited as a new therapeutic approach. In this study, we are interested to evaluate if sodium selenite and G-Rh2 combination results in a synergistic anticancer effect that could contribute to lower systemic toxicity. METHODS: We observed the synergistic antitumor effect by combination of sodium selenite and G-Rh2 on HCT-116 human Colorectal carcinoma cells in vitro. Cell growth, viability, cell cycle progression and cell apoptosis, Bax/Bcl2 ratio, caspase-3 expression, reactive oxygen species (ROS) production and autophagy were evaluated. RESULTS: The results showed that sodium selenite and G-Rh2 combination have a synergistic effect on cell growth inhibition (57%) compared with sodium selenite (25%) and G-Rh2 alone (28%) after 24hours of treatment. This combination also induced G1 and S phase arrest simultaneously and increased apoptosis rate. The results also indicated that Bax/Bcl2 ratio and caspase-3 expression, known as proapoptotic factors, were increased in the presence of sodium selenite and G-Rh2 alone. However, combined drug treatment results in a more significant increase in Bax/Bcl2 ratio and caspase-3 expression (P < 0. 05). In addition, this combination significantly induces a depletion of ROS production and autophagy, compared to control, sodium selenite and G-Rh2 alone (P < 0. 05). CONCLUSION: sodium selenite and ginsenoside Rh2 combination may be a more effective treatment for human Colorectal carcinoma and is a promising chemotherapeutic approach for malignant tumors.

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    APA: Copy

    Zhu, Changlai, LIU, FANG, Qian, Wenbo, Zhang, Tianyi, & Li, Feng. (2016). Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. ARCHIVES OF IRANIAN MEDICINE, 19(1), 23-29. SID. https://sid.ir/paper/281725/en

    Vancouver: Copy

    Zhu Changlai, LIU FANG, Qian Wenbo, Zhang Tianyi, Li Feng. Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2016;19(1):23-29. Available from: https://sid.ir/paper/281725/en

    IEEE: Copy

    Changlai Zhu, FANG LIU, Wenbo Qian, Tianyi Zhang, and Feng Li, “Combined Effect of Sodium Selenite and Ginsenoside Rh2 on HCT116 Human Colorectal Carcinoma Cells,” ARCHIVES OF IRANIAN MEDICINE, vol. 19, no. 1, pp. 23–29, 2016, [Online]. Available: https://sid.ir/paper/281725/en

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