Intravenous Immunoglobin Utilization Study in a Teaching Hospital

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Rezaie Nader; Shajareh Elham; MOTAMEDI MOHAMMAD REZA; GHANBARI BEHROOZ; Pakdaman Nashmin; FARASATINASAB MARYAM

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2019 | Volume:22 | Issue:5 Page(s): 232-235

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Title

Intravenous Immunoglobin Utilization Study in a Teaching Hospital

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Keywords

Drug utilization evaluation

Inflammatory neurological disorders

Intravenous immunoglobulin

IVIG

Abstract

Background: Intravenous immunoglobulin (IVIG) is an immunomodulating agent that has several actions. The aim of this study was to investigate the indications of IVIG according to available evidence and the cost in our center. Methods: This retrospective study was conducted between September 2017 and June 2018 at a teaching hospital affiliated with Iran University of Medical Sciences, Tehran, Iran. Patients’ demographic data and disease, indication for IVIG use, its dosage and treatment regimen and previous and concurrent treatments were assessed. The collected data were compared with the present criteria for the pattern of IVIG usage. The last version of Lexicomp® was used as the reference for indications of the administrated drug and its dosage. Results: A total of 119 patients received IVIG during the study period. The wards with the most frequent IVIG prescription were the neurology (46. 2%) and neonatal intensive care unit (21%). The most common reasons of IVIG therapy were various Inflammatory neurological disorders. IVIG was used in 22, 43 and 54 cases according to on-label, off-label and other indications, respectively. The total price was higher for off-label indications for IVIG ($254 343. 75) than on-label indications ($152 625). As well, $107 250 was exhausted for cases in which there was not sufficient evidence. Conclusion: One important aspects of this study was the use of IVIG in cases other than on-label indications. Although a number of studies support IVIG therapy in some diseases, further trials are needed to establish efficacy and safety in these fields.

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APA: Copy

Rezaie, Nader, Shajareh, Elham, MOTAMEDI, MOHAMMAD REZA, GHANBARI, BEHROOZ, Pakdaman, Nashmin, & FARASATINASAB, MARYAM. (2019). Intravenous Immunoglobin Utilization Study in a Teaching Hospital. ARCHIVES OF IRANIAN MEDICINE, 22(5), 232-235. SID. https://sid.ir/paper/281782/en

Vancouver: Copy

Rezaie Nader, Shajareh Elham, MOTAMEDI MOHAMMAD REZA, GHANBARI BEHROOZ, Pakdaman Nashmin, FARASATINASAB MARYAM. Intravenous Immunoglobin Utilization Study in a Teaching Hospital. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2019;22(5):232-235. Available from: https://sid.ir/paper/281782/en

IEEE: Copy

Nader Rezaie, Elham Shajareh, MOHAMMAD REZA MOTAMEDI, BEHROOZ GHANBARI, Nashmin Pakdaman, and MARYAM FARASATINASAB, “Intravenous Immunoglobin Utilization Study in a Teaching Hospital,” ARCHIVES OF IRANIAN MEDICINE, vol. 22, no. 5, pp. 232–235, 2019, [Online]. Available: https://sid.ir/paper/281782/en

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