مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

179
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

79
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Systematic Review: Prolonged versus Intermittent Infusion of Antibiotics in Acute and Severe Infections: A Meta-analysis

Pages

  612-626

Abstract

 Background: Acute and severe Infections are an absolute indication for the use of intravenous broad-spectrum Antibiotics. However, previous studies have found inconsistent clinical advantages of prolonged (extended [≥ 3-hour infusion] or continuous [24-hour fixed rate infusion]) over intermittent (6, or 8, or 12 interval hours infusion) infusion. The clinical superiority between prolonged and Intermittent infusion in treating acute and severe Infections thus continues to be elusive. We conducted a meta-analysis to summarize all published randomized controlled trials (RCTs), prospective and retrospective observational studies to determine whether Prolonged infusion, compared to Intermittent infusion, is correlated with lower mortality and better clinical outcome. Methods: We performed a literature search using MEDLINE (source PubMed, January 1, 1966 to August 31, 2018) and EMBASE (January 1, 1980 to August 31, 2018) with no restrictions to collect RCTs and observational studies comparing Prolonged infusion with Intermittent infusion of the same intravenous administered Antibiotics among adult hospitalized patients. A total of 43 studies including 30 RCTs, 5 prospective observational studies and 8 retrospective observational studies were identified. Results: In comparison with Intermittent infusion, Prolonged infusion of Antibiotics was associated with a reduction in all-cause mortality (pooled relative risk [RR] = 0. 77, 95% confidence interval [CI] = 0. 66– 0. 89) and improvement in clinical cure (RR = 1. 11, 95% CI = 1. 04– 1. 19), which was also observed in subgroups such as non-RCTs (mortality, RR = 0. 63, 95% CI = 0. 48– 0. 81; clinical cure RR = 1. 33, 95% CI = 1. 13– 1. 57) or studies with patients and APACHE II scores  15 (mortality, RR = 0. 74, 95% CI 0. 63– 0. 89; clinical cure RR = 1. 19, 95% CI = 1. 07– 1. 32). Moreover, in RCTs, mortality (RR = 0. 86, 95% CI 0. 72– 1. 03) between the two dosing strategies was not remarkably changed but clinical cure (RR = 1. 07, 95% CI = 1. 01– 1. 13) showed a significant advantage for Prolonged infusion. Additionally, no significant differences in mortality between the two dosing strategies was found (RR = 0. 87, 95% CI = 0. 70– 1. 09) but a distinct improvement in clinical cure was observed (RR = 1. 14, 95% CI = 1. 02– 1. 28) in the Prolonged infusion group for septic patients. Among two infusion modes, statistically significant severe adverse events were not reported (RR=0. 83, 95% CI = 0. 62– 1. 13). Conclusion: Better outcomes in hospitalized patients, especially in those who were critical ill, were reported in Prolonged infusion of intravenous Antibiotics compared with traditional Intermittent infusion.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Luo, Jieyu, Liao, Jinli, Cai, Ruibin, liu, Jingjing, Huang, Zhenhua, Cheng, Yunjiu, Yang, Zhen, & Liu, Zhihao. (2019). Systematic Review: Prolonged versus Intermittent Infusion of Antibiotics in Acute and Severe Infections: A Meta-analysis. ARCHIVES OF IRANIAN MEDICINE, 22(10), 612-626. SID. https://sid.ir/paper/281884/en

    Vancouver: Copy

    Luo Jieyu, Liao Jinli, Cai Ruibin, liu Jingjing, Huang Zhenhua, Cheng Yunjiu, Yang Zhen, Liu Zhihao. Systematic Review: Prolonged versus Intermittent Infusion of Antibiotics in Acute and Severe Infections: A Meta-analysis. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2019;22(10):612-626. Available from: https://sid.ir/paper/281884/en

    IEEE: Copy

    Jieyu Luo, Jinli Liao, Ruibin Cai, Jingjing liu, Zhenhua Huang, Yunjiu Cheng, Zhen Yang, and Zhihao Liu, “Systematic Review: Prolonged versus Intermittent Infusion of Antibiotics in Acute and Severe Infections: A Meta-analysis,” ARCHIVES OF IRANIAN MEDICINE, vol. 22, no. 10, pp. 612–626, 2019, [Online]. Available: https://sid.ir/paper/281884/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button