EFFECT OF FLIP ANGLE ON THE CORRELATION BETWEEN SIGNAL INTENSITY AND DIFFERENT CONCENTRATIONS OF IRON OXIDE NANOPARTICLES USING T1-WEIGHTED TURBO-FLASH INVERSION RECOVERY SEQUENCE

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GHAREHAGHAJI NAHIDEH; NAZARPOOR MAHMOOD; SAHARKHIZ HODAISEH

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Journal: Iranian Journal of Radiology Year:2015 | Volume:12 | Issue:2 Page(s): 0-0

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Title

EFFECT OF FLIP ANGLE ON THE CORRELATION BETWEEN SIGNAL INTENSITY AND DIFFERENT CONCENTRATIONS OF IRON OXIDE NANOPARTICLES USING T1-WEIGHTED TURBO-FLASH INVERSION RECOVERY SEQUENCE

Author(s)

GHAREHAGHAJI NAHIDEH | NAZARPOOR MAHMOOD | SAHARKHIZ HODAISEH | Issue Writer Certificate

Keywords

IRON OXIDE NANOPARTICLES

MAGNETIC RESONANCE IMAGING

INVERSION RECOVERY

Abstract

Background: Ultrasmall superparamagnetic IRON OXIDE NANOPARTICLES have been used as a blood pool contrast agent for magnetic resonance angiography and perfusion studies. Linear relationship between signal intensity (SI) and nanoparticle concentration is essential for perfusion measurement.Objectives: The aim of this study was to investigate the effect of different flip angles on maximum SI and the linear relationship between SI and different concentrations of IRON OXIDE NANOPARTICLES using T1-weighted Turbo-FLASH (fast low angle shot) INVERSION RECOVERY sequence to find the optimum flip angle for perfusion measurement.Materials and Methods: This in vitro study was performed using carboxydextran coated IRON OXIDE NANOPARTICLES with 20 nm hydrodynamic size. Different concentrations of nanoparticles between 0 and 500 mmol Fe/L were prepared. MR imaging was performed using T1-weighted Turbo-FLASH INVERSION RECOVERY sequence. Applied flip angles were 10-45o (interval of 5o). Then the maximum SI resulted by each concentration of nanoparticles was measured. Linear relationship between SI and nanoparticle concentration was evaluated regarding square correlations of 0.95 and 0.99. Coil non-uniformity was considered to obtain accurate SI of each image.Results: The maximum SI was obtained at the highest applied flip angle (45o). The linear relationship between SI and nanoparticle concentration was seen up to 112.21 and 98.83 mmol Fe/L for the short (10o) and the long (45o) flip angles, respectively (R2=0.95). These values were reduced up to 48.54 and 42.73 mmol Fe/L for these flip angles with R2 of 0.99.Conclusions: The maximum SI will be increased at higher flip angles with non-linear relationship between SI and nanoparticle concentration. The result shows that an increase in the flip angle leads to a decrease in the range of the linearity. The optimum flip angle which is suitable for perfusion measurement was obtained at 10o for our imaging parameters and sequence. The results of this study may be used in in vivo perfusion measurements.

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APA: Copy

GHAREHAGHAJI, NAHIDEH, NAZARPOOR, MAHMOOD, & SAHARKHIZ, HODAISEH. (2015). EFFECT OF FLIP ANGLE ON THE CORRELATION BETWEEN SIGNAL INTENSITY AND DIFFERENT CONCENTRATIONS OF IRON OXIDE NANOPARTICLES USING T1-WEIGHTED TURBO-FLASH INVERSION RECOVERY SEQUENCE. IRANIAN JOURNAL OF RADIOLOGY, 12(2), 0-0. SID. https://sid.ir/paper/284376/en

Vancouver: Copy

GHAREHAGHAJI NAHIDEH, NAZARPOOR MAHMOOD, SAHARKHIZ HODAISEH. EFFECT OF FLIP ANGLE ON THE CORRELATION BETWEEN SIGNAL INTENSITY AND DIFFERENT CONCENTRATIONS OF IRON OXIDE NANOPARTICLES USING T1-WEIGHTED TURBO-FLASH INVERSION RECOVERY SEQUENCE. IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2015;12(2):0-0. Available from: https://sid.ir/paper/284376/en

IEEE: Copy

NAHIDEH GHAREHAGHAJI, MAHMOOD NAZARPOOR, and HODAISEH SAHARKHIZ, “EFFECT OF FLIP ANGLE ON THE CORRELATION BETWEEN SIGNAL INTENSITY AND DIFFERENT CONCENTRATIONS OF IRON OXIDE NANOPARTICLES USING T1-WEIGHTED TURBO-FLASH INVERSION RECOVERY SEQUENCE,” IRANIAN JOURNAL OF RADIOLOGY, vol. 12, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/284376/en

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