Variability and Reliability of Normal Liver 18F-FDG Standardized Uptake Value in Relation to Placement of Volume of Interest (NUCLEAR MEDICINE)

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Liu Guobing; Hu Yan; Pang Lifang; Pengcheng Hu1 Haojun; Hu Pengcheng; Shi Hongcheng

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Journal: Iranian Journal of Radiology Year:2019 | Volume:16 | Issue:2 Page(s): 0-0

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Title

Variability and Reliability of Normal Liver 18F-FDG Standardized Uptake Value in Relation to Placement of Volume of Interest (NUCLEAR MEDICINE)

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Keywords

Fluoro

Deoxy

Glucose

Positron Emission Tomography

Computed Tomography

Standardized Uptake Value

Liver

Abstract

Background: The impact of volume-of-interest (VOI) placement on Liver standardized-uptake-value (SUV) measurement remains unclear. Objectives: To investigate variability and reliability of Liver SUV in relation to placement of VOI within the right lobe of the Liver. Patients and Methods: Positron Emission Tomography-Computed Tomography (PET/CT) of 343 patients with normal Liver were retrieved. Liver mean SUV (SUVmean) were measured by placing spherical VOIs at upper, portal vein and lower level of the right-lobe Liver. The general linear model, Bland-Altman analysis, one-way ANOVA were performed and the intraclass correlation coefficients (ICC) were calculated to identify impacts of reader and VOI position on variations of Liver SUVmean. Results: The Liver SUVmean at the upper, lower and portal vein level were 1. 85 0. 435, 1. 88 0. 409, and 1. 89 0. 414, respectively, with no significant inter-location difference (P = 0. 449). The coefficients of variation were close among locations (21. 9%-23. 5%). The inter-location ICCs controlling for reader were 0. 955 for reader 1 and 0. 980 for reader 2, while the inter-reader ICCs controlling for location were between 0. 930 and 0. 937, indicating great reliability and reproducibility. However, inter-reader bias of SUVmean were significantly different among locations (P < 0. 001). Bias at portal vein level (0. 069 0. 112) was significantly larger than those at the upper level (0. 004 0. 144, P < 0. 001) and lower level (0. 002 0. 136, P < 0. 001). Conclusion: Liver SUVmean measured by placing VOI at the portal vein level exhibited a relatively larger variation and less precision between readers, which was not recommended.

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APA: Copy

Liu, Guobing, Hu, Yan, Pang, Lifang, Pengcheng Hu1, Haojun, Hu, Pengcheng, & Shi, Hongcheng. (2019). Variability and Reliability of Normal Liver 18F-FDG Standardized Uptake Value in Relation to Placement of Volume of Interest (NUCLEAR MEDICINE). IRANIAN JOURNAL OF RADIOLOGY, 16(2), 0-0. SID. https://sid.ir/paper/284512/en

Vancouver: Copy

Liu Guobing, Hu Yan, Pang Lifang, Pengcheng Hu1 Haojun, Hu Pengcheng, Shi Hongcheng. Variability and Reliability of Normal Liver 18F-FDG Standardized Uptake Value in Relation to Placement of Volume of Interest (NUCLEAR MEDICINE). IRANIAN JOURNAL OF RADIOLOGY[Internet]. 2019;16(2):0-0. Available from: https://sid.ir/paper/284512/en

IEEE: Copy

Guobing Liu, Yan Hu, Lifang Pang, Haojun Pengcheng Hu1, Pengcheng Hu, and Hongcheng Shi, “Variability and Reliability of Normal Liver 18F-FDG Standardized Uptake Value in Relation to Placement of Volume of Interest (NUCLEAR MEDICINE),” IRANIAN JOURNAL OF RADIOLOGY, vol. 16, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/284512/en

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