EFFECTS OF MDMA (ECSTASY) ON OOCYTE QUALITY AND FERTILIZATION RATE IN MICE

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HAJI MAGHSOUDI F.; KHALILI MOHAMMAD ALI; KARIMZADEH A.

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Journal: Journal of Reproduction & Infertility Year:2010 | Volume:11 | Issue:2 (43) Page(s): 77-85

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Title

EFFECTS OF MDMA (ECSTASY) ON OOCYTE QUALITY AND FERTILIZATION RATE IN MICE

Author(s)

HAJI MAGHSOUDI F. | KHALILI MOHAMMAD ALI | KARIMZADEH A. | Issue Writer Certificate

Keywords

BETA-KETO-3Q1

4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA)Q2

ECSTASYQ2

FERTILITYQ2

FERTILIZATIONQ2

IN-VITRO FERTILIZATIONQ1

METHAMPHETAMINEQ1

OOCYTEQ1

OVARYQ1

Abstract

Introduction: ECSTASY drug abuse is relatively common among the youth undergoing psychosocial stresses. Categorized as a stimulant drug, ECSTASY has nervous, cardiac and immunological side-effects. The endocrine system is not spared from the harmful effects of the drug and it could influence ovulation by exerting its effects on the hypothalamic-hypophyseal-gonadal axis. The aim of this study was to evaluate the effects of ECSTASY on the quality of OOCYTEs and on FERTILIZATION rate in mice.Materials and Methods: Thirty female NMRI mice were divided into three groups, after checking for their estrous cycles. At the beginning of each cycle, ECSTASY was administered intraperitoneally to the animals in groups A (a minimum dose of 5 mg/kg/day) and B (a maximum dose of 20 mg/kg/day). At the end of the second day, 10 IU PMSG, and at the end of the 4th day, 10 IU HCG were administered intra-peritoneally. The mice in group C underwent the same procedures except receiving ECSTASY. All the mice were sacrificed on the fifth day to aspirate their OOCYTEs for further evaluation. In-vitro FERTILIZATION was done using mature or MII OOCYTEs and FERTILIZATION was checked after 5 hours. The results were later statistically analyzed.Results: The number of retrieved OOCYTEs was similar between the experimental and control groups. However, the rate of mature OOCYTEs (MII) was significantly higher (p=0.0001) in the controls (31.2%) than the mice in groups A (15.2%) and B (12.8%). Moreover, FERTILIZATION rate was significantly higher in the controls than the experi-mental groups. Conclusion: Administration of ECSTASY in mice can affect both OOCYTE maturity and the FERTILIZATION potential of OOCYTEs. The overall effects of ECSTASY on embryo devel-opment and implantation needs further studies to reach a definitive conclusion.

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APA: Copy

HAJI MAGHSOUDI, F., KHALILI, MOHAMMAD ALI, & KARIMZADEH, A.. (2010). EFFECTS OF MDMA (ECSTASY) ON OOCYTE QUALITY AND FERTILIZATION RATE IN MICE . JOURNAL OF REPRODUCTION AND INFERTILITY, 11(2 (43)), 77-85. SID. https://sid.ir/paper/28529/en

Vancouver: Copy

HAJI MAGHSOUDI F., KHALILI MOHAMMAD ALI, KARIMZADEH A.. EFFECTS OF MDMA (ECSTASY) ON OOCYTE QUALITY AND FERTILIZATION RATE IN MICE . JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2010;11(2 (43)):77-85. Available from: https://sid.ir/paper/28529/en

IEEE: Copy

F. HAJI MAGHSOUDI, MOHAMMAD ALI KHALILI, and A. KARIMZADEH, “EFFECTS OF MDMA (ECSTASY) ON OOCYTE QUALITY AND FERTILIZATION RATE IN MICE ,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 11, no. 2 (43), pp. 77–85, 2010, [Online]. Available: https://sid.ir/paper/28529/en

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