EVALUATION OF THE ROLE OF MANNITOL IN RADAIOPROTECTION OF AMIFOSTINE

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ABBASI M.R.; FOROUGHIZADEH MOGHADDAM M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2003 | Volume:1 | Issue:3 Page(s): 151-155

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Information Journal Paper

Title

EVALUATION OF THE ROLE OF MANNITOL IN RADAIOPROTECTION OF AMIFOSTINE

Author(s)

ABBASI M.R. | FOROUGHIZADEH MOGHADDAM M. | Issue Writer Certificate

Keywords

IONIZING RADIATION

FREE RADICALS

MANNITOL

AMIFOSTINE

MICRONUCLEI

LD50/30.

Abstract

Background: MANNITOL is present in the Ethyol ® (the trade name of AMIFOSTINE) as an excipient. The mechanism of radioprotection of AMIFOSTINE is radical scavenging. Since MANNITOL is another known radical scavenger, we studied the probable additive or synergistic effect of MANNITOL on the effect of AMIFOSTINE. Material and Methods: Mice were irradiated with Co-60 γ -ray in the presence 400mg/kg MANNITOL alone or in combination with 400mg/kg AMIFOSTINE. Survival of mice was assessed within 30 days after irradiation (LD 50/30). Moreover, the protective effect of drugs was evaluated using MICRONUCLEI (MN) assay. Slides were prepared using femoral bone marrow flush and stained in May-Giemsa. The frequency of MN was determined in polychromatic erythrocytes (PCE) for each sample. Results: Similar LD50/30.was observed for irradiated mice in the presence of AMIFOSTINE alone or in combinations with MANNITOL. High frequency of MN was produced by 3 Gy γ -rays. AMIFOSTINE reduced radiation induced MN dramatically, but MANNITOL had no effect on γ -rays induced MN. Combination of MANNITOL with AMIFOSTINE did not change the effect of AMIFOSTINE alone. Conclusion: Radioprotection of ethyol is due to the effect of AMIFOSTINE. Presence of MANNITOL apparently has no role in radioprotective effect of AMIFOSTINE

Cites

DIFFERENT ASPECTS OF CYTOCHALASIN B BLOCKED MICRONUCLEUS CYTOME (CBMN CYT) ASSAY AS A COMPREHENSIVE MEASUREMENT TOOL FOR RADIOBIOLOGICAL STUDIES, BIOLOGICAL DOSIMETRY AND GENOME INSTABILITY

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APA: Copy

ABBASI, M.R., FOROUGHIZADEH MOGHADDAM, M.,. (2003). EVALUATION OF THE ROLE OF MANNITOL IN RADAIOPROTECTION OF AMIFOSTINE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 1(3), 151-155. SID. https://sid.ir/paper/286295/en

Vancouver: Copy

ABBASI M.R., FOROUGHIZADEH MOGHADDAM M.. EVALUATION OF THE ROLE OF MANNITOL IN RADAIOPROTECTION OF AMIFOSTINE. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2003;1(3):151-155. Available from: https://sid.ir/paper/286295/en

IEEE: Copy

M.R. ABBASI, M. FOROUGHIZADEH MOGHADDAM, an, “EVALUATION OF THE ROLE OF MANNITOL IN RADAIOPROTECTION OF AMIFOSTINE,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 1, no. 3, pp. 151–155, 2003, [Online]. Available: https://sid.ir/paper/286295/en

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