G2 CHROMOSOMAL RADIO SENSITIVITY AND BACKGROUND FREQUENCY OF SISTER CHROMATID EXCHANGES OF PERIPHERAL BLOOD LYMPHOCYTES OF BREAST CANCER PATIENTS

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MOZDARANI H.; ZIAEE MASHHADI A.H.; ALIMOHAMMADI Z.

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Paper Information

Journal: International Journal of Radiation Research Year:2011 | Volume:9 | Issue:3 Page(s): 167-174

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Title

G2 CHROMOSOMAL RADIO SENSITIVITY AND BACKGROUND FREQUENCY OF SISTER CHROMATID EXCHANGES OF PERIPHERAL BLOOD LYMPHOCYTES OF BREAST CANCER PATIENTS

Author(s)

MOZDARANI H. | ZIAEE MASHHADI A.H. | ALIMOHAMMADI Z. | Issue Writer Certificate

Keywords

RADIO SENSITIVITY

CHROMATID BREAKS

SCE

BREAST CANCER PATIENTS

LYMPHOCYTES

Abstract

Background: Chromosomal alterations play an important role in carcinogenesis. Enhanced chromosomal RADIO SENSITIVITY is shown for many cancer predisposition conditions including breast cancer. In this study chromosomal RADIO SENSITIVITY and the frequency of background sister chromnatid exchanges (SCE) in LYMPHOCYTES of normal individuals and BREAST CANCER PATIENTS was compared.Materials and Methods: G2 assay was performed on peripheral blood LYMPHOCYTES obtained from 60 BREAST CANCER PATIENTS and 50 normal control. Blood culture was initiated and cells were irradiated with 1 Gy gammarays 4 h prior to harvesting. After metaphase preparations and slide making, chromatid aberrations were scored. For SCE studies, blood samples from 30 BREAST CANCER PATIENTS and 30 normal control were studied. 24 hours after culture initiation, 5- bromodeoxy uridine (BrdU) was added and cells were harvested 48 hours after addition of BrdU. Slides were stained in Hoechst 33258 and exposed to UVA source, then stained in Giemsa.Results: Results indicated that the frequency of radiation induced CHROMATID BREAKS was significantly higher in BREAST CANCER PATIENTS compared to normal control (p<0.01). From RADIO SENSITIVITY point of view, 12% of normal control and 47% of BREAST CANCER PATIENTS showed elevated chromatid RADIO SENSITIVITY. Frequency of background SCE was significantly higher in LYMPHOCYTES of BREAST CANCER PATIENTS compared to LYMPHOCYTES of control (p<0.05).Conclusion: Elevated chromosomal RADIO SENSITIVITY and higher frequency of SCE in LYMPHOCYTES of BREAST CANCER PATIENTS might be indicative of genomic instability of these cells. Increased RADIO SENSITIVITY could also be due to defects in DNA repair genes involved in breast cancer formation.

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APA: Copy

MOZDARANI, H., ZIAEE MASHHADI, A.H., & ALIMOHAMMADI, Z.. (2011). G₂ CHROMOSOMAL RADIO SENSITIVITY AND BACKGROUND FREQUENCY OF SISTER CHROMATID EXCHANGES OF PERIPHERAL BLOOD LYMPHOCYTES OF BREAST CANCER PATIENTS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 9(3), 167-174. SID. https://sid.ir/paper/286565/en

Vancouver: Copy

MOZDARANI H., ZIAEE MASHHADI A.H., ALIMOHAMMADI Z.. G₂ CHROMOSOMAL RADIO SENSITIVITY AND BACKGROUND FREQUENCY OF SISTER CHROMATID EXCHANGES OF PERIPHERAL BLOOD LYMPHOCYTES OF BREAST CANCER PATIENTS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2011;9(3):167-174. Available from: https://sid.ir/paper/286565/en

IEEE: Copy

H. MOZDARANI, A.H. ZIAEE MASHHADI, and Z. ALIMOHAMMADI, “G₂ CHROMOSOMAL RADIO SENSITIVITY AND BACKGROUND FREQUENCY OF SISTER CHROMATID EXCHANGES OF PERIPHERAL BLOOD LYMPHOCYTES OF BREAST CANCER PATIENTS,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 9, no. 3, pp. 167–174, 2011, [Online]. Available: https://sid.ir/paper/286565/en

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