RADIO-ADAPTIVE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING BYSTANDER EFFECTS INDUCED BY PREIRRADIATED CHO-K1 CELLS USING THE MICRONUCLEUS ASSAY

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SHIRANI SH.; MOZDARANI HOSSEIN; MAHMOODZADEH A.; SALIMI M.

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Journal: International Journal of Radiation Research Year:2015 | Volume:13 | Issue:2 Page(s): 151-156

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Title

RADIO-ADAPTIVE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING BYSTANDER EFFECTS INDUCED BY PREIRRADIATED CHO-K1 CELLS USING THE MICRONUCLEUS ASSAY

Author(s)

SHIRANI SH. | MOZDARANI HOSSEIN | MAHMOODZADEH A. | SALIMI M. | Issue Writer Certificate

Keywords

BYSTANDER EFFECT

RADIO-ADAPTIVE RESPONSE

GAMMA RAYS

MICRONUCLEUS ASSAY

Abstract

Background: RADIO-ADAPTIVE RESPONSE and BYSTANDER EFFECTs are known phenomena occurring in cells following exposure to ionizing radiation (IR). In this study we examined possible radio-adaptation of lymphocytes following BYSTANDER EFFECTs induced by CHO-K1 cells. Materials and Methods: Whole blood and CHO-K1 cells were cultured in RPMI-1640 complete medium. Cells were separately irradiated with various doses of GAMMA RAYS. A co-culture was set to examine the BYSTANDER EFFECTs induced by CHO-K1 cells on lymphocytes exposed later to a challenge dose of 4 Gy. Treated cells were exposed to cytochalasin-B to arrest cells in cytokinesis stage. Micronucleus (MN) as end point was scored in binucleate cells after staining in Giemsa.Results: The frequency of MN increased significantly with increasing dose of radiation both in lymphocytes and CHO-K1 cells (p<0.001). Although, no significant difference was observed between control non-irradiated cells and those exposed to 0.2 Gy (p>0.05). Co-culture of the non-irradiated lymphocytes with pre-irradiated CHO-K1 cells significantly reduced the mean frequency of MN in lymphocytes irradiated with a dose of 4Gy (p<0.001).Conclusion: Results showed that BYSTANDER EFFECTs induced by gamma-irradiated CHO-K1 cells led to induction of RADIO-ADAPTIVE RESPONSE in lymphocytes. The mechanism by which RADIO-ADAPTIVE RESPONSE is induced following BYSTANDER EFFECT is not clearly known, however cellular signaling and genome instability induced in cells indirectly might be considered as possible triggering events for RADIO-ADAPTIVE RESPONSE.

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APA: Copy

SHIRANI, SH., MOZDARANI, HOSSEIN, MAHMOODZADEH, A., & SALIMI, M.. (2015). RADIO-ADAPTIVE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING BYSTANDER EFFECTS INDUCED BY PREIRRADIATED CHO-K1 CELLS USING THE MICRONUCLEUS ASSAY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 13(2), 151-156. SID. https://sid.ir/paper/286621/en

Vancouver: Copy

SHIRANI SH., MOZDARANI HOSSEIN, MAHMOODZADEH A., SALIMI M.. RADIO-ADAPTIVE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING BYSTANDER EFFECTS INDUCED BY PREIRRADIATED CHO-K1 CELLS USING THE MICRONUCLEUS ASSAY. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2015;13(2):151-156. Available from: https://sid.ir/paper/286621/en

IEEE: Copy

SH. SHIRANI, HOSSEIN MOZDARANI, A. MAHMOODZADEH, and M. SALIMI, “RADIO-ADAPTIVE RESPONSE OF PERIPHERAL BLOOD LYMPHOCYTES FOLLOWING BYSTANDER EFFECTS INDUCED BY PREIRRADIATED CHO-K1 CELLS USING THE MICRONUCLEUS ASSAY,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 13, no. 2, pp. 151–156, 2015, [Online]. Available: https://sid.ir/paper/286621/en

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