مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE BIOLOGICAL EFFECTS INDUCED BY HIGH-CHARGED AND ENERGY PARTICLES AND ITS APPLICATION IN CANCER THERAPY

Pages

  1-7

Abstract

 The radiobiological effects of high atomic number and energy (HZE parcles) ion beams are of interest for radioprotecon in space and tumor RADIOTHERAPY. Space radiaon mainly consists of heavy charged parcles from protons to iron ions, which is disnct from common terrestrial forms of radiaon. HZE parcles pose a significant cancer risk to astronauts on prolonged space missions. With high delivered energies and intense ionizaon, HZE parcles can damage not only the biological systems but also the shielding materials. HZE parcles are more effecve than low-LET radiaon likeg- or X-rays to induce genec mutaon and cancer. On Earth, similar ions are being used for targeted cancer therapy due to the advantage of the inverse dose profile, with delivering higher doses to the tumor while keeping lower doses to the surrounding ssues. In this review, we focus on the recent insights into the biological effects caused by HZE parcles and the corresponding mechanism. We also discuss the current applicaon of HZE parcle in cancer therapy. Understanding the mechanisms underlying the repair of DNA damage induced by HZE parcles contribute to accurately esmate the risks to human health associated with HZE parcle exposure and to improve the effecveness of tumor RADIOTHERAPY.

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    • Cite

    APA: Copy

    ZHU, J., REN, Z., CHEN, Y., & HU, BURONG. (). . , (), -. SID. https://sid.ir/paper/286696/en

    Vancouver: Copy

    ZHU J., REN Z., CHEN Y., HU BURONG. . [Internet]. ;():-. Available from: https://sid.ir/paper/286696/en

    IEEE: Copy

    J. ZHU, Z. REN, Y. CHEN, and BURONG HU, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/286696/en

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