مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

BONE MARROW RADIATION DOSIMETRY OF HIGH DOSE 131I TREATMENT IN DIFFERENTIATED THYROID CARCINOMA PATIENTS

Pages

  99-104

Abstract

 Background: Radiaon absorbed dose to the red bone marrow, a crical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablave therapies. The aim of this study was to calculate bone marrow radiaon dose by using MIRDOSE3 package program and to opmize the safe limit of acvity to be administered to the THYROID CANCER paents.Materials and Methods: In this study, 83 THYROID CANCER paents were divided into 3 groups based on the amount of acvity administered into the body. In the groups, 3700 MBq, 5550 MBq and 7400 MBq acvies were used respecvely. The curves of me-acvity were drawn from blood samples counts and effecve half-life and residence me were calculated. Correlaons of bone marrow radiaon dose and radioiodine effecve half-life were determined as a funcon of administered acvity via ANOVA test. Tg levels and tumour diameters were compared using Spearman’s correlaon.Results: The effecve half-lives of131I for three groups of whole-body, receiving 3700 MBq, 5550 MBq and 7400 MBq were calculated as 20.57±5.4, 17.8±5.8 and 18.7±3.9 hours, respecvely. The average bone marrow doses for 3 groups of paents were 0.32±0.08 Gy, 0.42±0.14 Gy and 0.60±0.24 Gy, respecvely.Conclusion: It was concluded that, the bone marrow dose to the paents sll remains within the recommended level even a9er administering an acvity of 7400 MBq of131I to the paents.

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    APA: Copy

    PARLAK, Y., DEMIR, MUSTAFA, CAVDAR, I., EREEES, S., GUMUSER, G., UYSAL, B., CAPA KAYA, G., KOC, M., & SAYIT, E.. (). . , (), -. SID. https://sid.ir/paper/286704/en

    Vancouver: Copy

    PARLAK Y., DEMIR MUSTAFA, CAVDAR I., EREEES S., GUMUSER G., UYSAL B., CAPA KAYA G., KOC M., SAYIT E.. . [Internet]. ;():-. Available from: https://sid.ir/paper/286704/en

    IEEE: Copy

    Y. PARLAK, MUSTAFA DEMIR, I. CAVDAR, S. EREEES, G. GUMUSER, B. UYSAL, G. CAPA KAYA, M. KOC, and E. SAYIT, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/286704/en

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