مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

311
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

201
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

POTENT RADIOPROTECTIVE EFFECT OF HERBAL IMMUNOMODULATOR DRUG (IMOD) ON MOUSE BONE MARROW ERYTHROCYTES AS ASSAYED WITH THE MICRONUCLEUS TEST

Pages

  221-228

Abstract

 Background: Although numerous natural or synthetic drugs have been tested for their radioprotective capacity, yet no suitable drug has been introduced for routine clinical use. In this study the radioprotective effect of "a new herbal IMMUNOMODULATOR" commercially known as IMOD, specifically made to decrease the side effects of HIV virus, was investigated on MOUSE BONE MARROW cells.Materials and Methods: Female NMRI mice (in a group of five) were exposed to 2 Gy gamma radiation following three days of intravenously injection (IV) of IMOD at various doses. Mice were sacrificed 48 and 72 h after irradiation. Bone marrow was flushed and slides for bone marrow smears were prepared according to standard method. After staining slides in May Grunwald and Giemsa, polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) were scored for presence of micronucleus (MN).Results: The results showed that gamma irradiation increased the frequency of micronuclei dramatically and excreted cytotoxic effect of cell proliferation. Injection of various doses of IMOD before irradiation however, led to a considerable reduction in the frequency of micronuclei in bone marrow erythrocytes as well as cellular toxicity.Conclusion: Results indicated radioprotective capability of IMOD with a dose reduction factor (DRF) of about 2.3 at a dose of 20 mg/kg body weight. The considerably high DRF might be indicative that IMOD besides being an IMMUNOMODULATOR might also posses’ antioxidant property.

Cites

References

  • No record.

    • Cite

    APA: Copy

    SHAKERI BOROUJENI, A., MOZDARANI, HOSSEIN, MAHMMOUDZADEH, M., & FAEGHI, F.. (2016). POTENT RADIOPROTECTIVE EFFECT OF HERBAL IMMUNOMODULATOR DRUG (IMOD) ON MOUSE BONE MARROW ERYTHROCYTES AS ASSAYED WITH THE MICRONUCLEUS TEST. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 14(3), 221-228. SID. https://sid.ir/paper/286717/en

    Vancouver: Copy

    SHAKERI BOROUJENI A., MOZDARANI HOSSEIN, MAHMMOUDZADEH M., FAEGHI F.. POTENT RADIOPROTECTIVE EFFECT OF HERBAL IMMUNOMODULATOR DRUG (IMOD) ON MOUSE BONE MARROW ERYTHROCYTES AS ASSAYED WITH THE MICRONUCLEUS TEST. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2016;14(3):221-228. Available from: https://sid.ir/paper/286717/en

    IEEE: Copy

    A. SHAKERI BOROUJENI, HOSSEIN MOZDARANI, M. MAHMMOUDZADEH, and F. FAEGHI, “POTENT RADIOPROTECTIVE EFFECT OF HERBAL IMMUNOMODULATOR DRUG (IMOD) ON MOUSE BONE MARROW ERYTHROCYTES AS ASSAYED WITH THE MICRONUCLEUS TEST,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 14, no. 3, pp. 221–228, 2016, [Online]. Available: https://sid.ir/paper/286717/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button