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Information Journal Paper

Title

Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice

Pages

  55-64

Abstract

 Background: Chamomile essential oil (CEO) hauls out from Matricaria chamomilla L., is a well-known anti-oxidant. Oxidative stress induces clastogenic and biochemical disorders after γ-irradiation of animals. Materials and Methods: Mice were divided into five groups. Control group received vehicle only. CEO-treated group received CEO. Irradiated group received vehicle and exposed to γ-rays. Pre-treated group received CEO ½ h before γ-rays exposure. Post-treated group received CEO ½ hour after γ-rays exposure. Peripheral-blood micronucleus (PMN), bone-marrow micronucleus (BMN), frequency of chromosomal aberrations (CAs), reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (PGx) and myeloperoxidase (MPO), lactate dehydrogenase (LDH) and tumor necrosis factor-α (TNF-α ) parameters were assessed. Results: In irradiated mice group, PMN score, BMN occurrence and CAs were increased when compared with control mice group. In addition, significant increases in levels of liver lipid peroxidation (LP); expressed as MDA and TNF-α . In addition, activities of liver MPO and LDH were found. Besides, significant decreases in content of GSH, activities of SOD and PGx in liver tissues were recognized. CEO treatment (1. 0 g/kg body weight) before-and after-irradiation ameliorated all these biochemical indices, as well as cytogenetic alterations induced by γ-rays when compared with irradiated group, indicating that pre-or post-treatment with CEO significantly attenuates the acute hazards caused by γ-rays exposure. Conclusion: The data suggest that CEO possesses a radioprotective potential against γ-radiation induced cytogenetic and biochemical damages in mice.

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    Cite

    APA: Copy

    Tawfik, s.s., AHMED, M.M., Said, z.s., & MOHAMED, M.R.. (2018). Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 16(1), 55-64. SID. https://sid.ir/paper/286759/en

    Vancouver: Copy

    Tawfik s.s., AHMED M.M., Said z.s., MOHAMED M.R.. Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2018;16(1):55-64. Available from: https://sid.ir/paper/286759/en

    IEEE: Copy

    s.s. Tawfik, M.M. AHMED, z.s. Said, and M.R. MOHAMED, “Cytogenetic and biochemical competency of chamomile essential oil against γ-rays induced mutagenic effects in mice,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 16, no. 1, pp. 55–64, 2018, [Online]. Available: https://sid.ir/paper/286759/en

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