مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

199
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

104
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Genotype-phenotype association of TGF-β 1 and GST with chemo-radiotherapy induced toxicity

Pages

  15-23

Abstract

 Background: Normal tissue toxicity continues to remain as a major challenge for radiation oncologists for delivering the total dose to the tumour cells in cancer patients. Cellular, molecular and plasma based early biomarkers to predict the overreactions and non-overreactions of normal tissue toxicity before the initiation of radiotherapy can be valuable for personalised treatment. The aim of the current study was to analyse the interrelationship between polymorphisms in glutathione S-Transferases (GSTs) and Transforming Growth Factor-β 1 (TGF-ß 1), the plasma level/activity of these proteins with the development of chemo-radiotherapy induced oral mucositis and skin reaction in head and neck cancer (HNC) patients. Materials and Methods: We analysed polymorphisms in TGF-β 1 and GST by restriction digestion of the PCR amplified products and we also assessed circulating TGF-β 1 levels and GST activity by Enzyme Linked Immunosorbent Assay (ELISA). Results: The results indicate that pre-radiotherapy plasma TGF-β 1 levels and total GST activity has no correlation with radiation induced normal tissue skin reaction and oral mucositis in HNC patients. Conclusion: The selected polymorphisms in TGF-β 1 and GST had no influence on TGF-β 1 levels and total GST activity. Plasma TGF-β 1 and GST activity was not affected by the presence of selected polymorphisms and lacks significance in predicting skin reaction and oral mucositis prior to chemo-radiotherapy.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Goutham, H.V., Mumbrekar, K.D., Hitendra, N., Vadhiraja, B.M., Fernandes, D.J., & SATISH RAO, B.S.. (2017). Genotype-phenotype association of TGF-β 1 and GST with chemo-radiotherapy induced toxicity. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(1), 15-23. SID. https://sid.ir/paper/286779/en

    Vancouver: Copy

    Goutham H.V., Mumbrekar K.D., Hitendra N., Vadhiraja B.M., Fernandes D.J., SATISH RAO B.S.. Genotype-phenotype association of TGF-β 1 and GST with chemo-radiotherapy induced toxicity. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(1):15-23. Available from: https://sid.ir/paper/286779/en

    IEEE: Copy

    H.V. Goutham, K.D. Mumbrekar, N. Hitendra, B.M. Vadhiraja, D.J. Fernandes, and B.S. SATISH RAO, “Genotype-phenotype association of TGF-β 1 and GST with chemo-radiotherapy induced toxicity,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 1, pp. 15–23, 2017, [Online]. Available: https://sid.ir/paper/286779/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button