Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer

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YU H.; TANG X.; Shu d.; GENG C.; GONG C.; Hang S.; CHEN D.

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Journal Paper

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Journal: International Journal of Radiation Research Year:2017 | Volume:15 | Issue:1 Page(s): 1-13

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Information Journal Paper

Title

Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer

Author(s)

Keywords

Multiple-field irradiation

BNCT

non-small cell lung cancer

radiation dose

Monte Carlo

Abstract

Background: Boron neutron capture therapy (BNCT) is a radiotherapy that combines biological targe ng and high linear energy transfer. A poten al therapeu c approach for non-small cell lung cancer (NSCLC) is considered. However, dose in lung tumor is not homogeneous, and it will reduce the effect of BNCT treatment. In order to improve the dose distribu on of BNCT, the mul-field irradia on strategy and its effects need to be explored. Materials and Methods: Common NSCLC model was defined in Chinese hybrid reference phantom and the boron concentra on in skin and tumor varied from 6 to 18 ppm and from 30 to 65 ppm, respec vely. Monte Carlo method for dose distribu on calcula on was used. Accelerator-based neutron source called “ Neuboron source” was used and mul-field source irradia on plans were designed to op mize the dose distribu on. Results: Under onefield irradia on, it was not feasible to perform BNCT, because the skin dose is unlikely to meet its dose limit. Under two-and three-field irradia on, the uniformity of tumor dose was improved and the maximum dose to organs at risk (OARs) decreased. If boron concentra on in skin was between 6-18 ppm, BNCT was feasible with the boron concentra on in tumor reaching about 57-60 ppm for two-field irradia on and 41-45 ppm for three-field irradia on, respec vely. Conclusion: The mul-field irradia on plan could improve the dose distribu on and the feasibility of BNCT for NSCLC. Theore cal distribu ons of Boron-10 were obtained to meet the treatable requirement of BNCT, which could provide a reference for NSCLC using BNCT in future mul ple-field irradia on.

Cites

A Monte Carlo study of SPECT in boron neutron capture therapy for a heterogeneous human phantom

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APA: Copy

YU, H., TANG, X., Shu, d., GENG, C., GONG, C., Hang, S., & CHEN, D.. (2017). Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(1), 1-13. SID. https://sid.ir/paper/286780/en

Vancouver: Copy

YU H., TANG X., Shu d., GENG C., GONG C., Hang S., CHEN D.. Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(1):1-13. Available from: https://sid.ir/paper/286780/en

IEEE: Copy

H. YU, X. TANG, d. Shu, C. GENG, C. GONG, S. Hang, and D. CHEN, “Impacts of multiple-field irradiation and boron concentration on the treatment of boron neutron capture therapy for non-small cell lung cancer,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 1, pp. 1–13, 2017, [Online]. Available: https://sid.ir/paper/286780/en

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