The use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma

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CHEN W.; LI J.; HONG L.; XING Z.; WANG F.; LI C.

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Journal Paper

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Journal: International Journal of Radiation Research Year:2017 | Volume:15 | Issue:4 Page(s): 363-369

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Title

The use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma

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Keywords

Nasopharyngeal carcinoma

radiotherapy

radiation injuries

magnetic resonance spectroscopy

Abstract

Background: This study aims to inves gate the metabolic characteris cs of radiotherapy-induced temporal lobe injury in elderly pa ents with Nasopharyngeal carcinoma using 1H-magne c resonance spectroscopy (MRS). Materials and Methods: Data were collected from 21 elderly pa ents and 33 young pa ents before and during therapy with different radia on dosages (20, 40, and 60 Gy). The Student’ s t-test was used to compare the 1H-MRS-based N-acetyl aspartate /Crea ne (NAA/Cr), Choline/Crea ne (Cho/ Cr), and NAA/Cho ra os in the temporal lobes. Results: Sta s cally significant differences in the NAA/Cr and NAA/Cho ra os was found between the two groups (P < 0. 05) at 20, 40, and 60 Gy. The Cho/Cr ra os (20/40/60 Gy) were 1. 82 ± 0. 16/1. 61 ± 0. 29/1. 37 ± 0. 13 and 1. 77 ± 0. 19/1. 48 ± 0. 17/1. 06 ± 0. 14 in the elderly and young pa ents, respec vely. We found significant differences between the two groups at the dosages of 40 and 60 Gy (P<0. 05). The decrease in the NAA/Cr and NAA/Cho ra os in the elderly group was significantly higher than that in the young pa ents with dosages of 20, 40, and 60 Gy. The decrease in the Cho/Cr ra o in the elderly group (2. 15%/11. 29%/12. 90%) was significantly lower than that in the young pa ents (3. 30%/15. 93%/17. 58%). Conclusion: Under the same radiotherapy pa

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APA: Copy

CHEN, W., LI, J., HONG, L., XING, Z., WANG, F., & LI, C.. (2017). The use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 15(4), 363-369. SID. https://sid.ir/paper/286899/en

Vancouver: Copy

CHEN W., LI J., HONG L., XING Z., WANG F., LI C.. The use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma. INTERNATIONAL JOURNAL OF RADIATION RESEARCH[Internet]. 2017;15(4):363-369. Available from: https://sid.ir/paper/286899/en

IEEE: Copy

W. CHEN, J. LI, L. HONG, Z. XING, F. WANG, and C. LI, “The use of 1H-magnetic resonance spectroscopy in studying radiation-induced injury of the brain in elderly and young patients with nasopharyngeal carcinoma,” INTERNATIONAL JOURNAL OF RADIATION RESEARCH, vol. 15, no. 4, pp. 363–369, 2017, [Online]. Available: https://sid.ir/paper/286899/en

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