EVALUATION OF ACETONITRILE DEPROTEINISATION OF THE SERUM SAMPLES FOR THE ANALYSIS OF DRUGS IN SERUM USING CAPILLARY ZONE ELECTROPHORESIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAFAATI A.R.; CLARK B.J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2002 | Volume:1 | Issue:1 Page(s): 43-46

Download Full-Text

View:

319

Download:

127

Cites:

Information Journal Paper

Title

EVALUATION OF ACETONITRILE DEPROTEINISATION OF THE SERUM SAMPLES FOR THE ANALYSIS OF DRUGS IN SERUM USING CAPILLARY ZONE ELECTROPHORESIS

Author(s)

SHAFAATI A.R. | CLARK B.J. | Issue Writer Certificate

Keywords

CAPILLARY ELECTROPHORESIS; SERUM; ACETONITRILE DEPROTEINISATION.

Abstract

Deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. In this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (CE) is evaluated. Some drugs with different ionic and protein binding properties were selected and dissolved in human serum. The efficiency of deproteinisation of spiked serum samples with acetonitrile and further analysis with CE was evaluated for each sample with special interest on the neutral drugs. The results showed that deproteinisation method is more efficient for charged molecules with low protein bindings. For neutral, relatively non-polar compounds (such as praziquantel), a MEKC method is preferred. For neutral, highly polar molecules (such as methimazole), other means of sample preparation must be considered.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAFAATI, A.R., & CLARK, B.J.. (2002). EVALUATION OF ACETONITRILE DEPROTEINISATION OF THE SERUM SAMPLES FOR THE ANALYSIS OF DRUGS IN SERUM USING CAPILLARY ZONE ELECTROPHORESIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 1(1), 43-46. SID. https://sid.ir/paper/286931/en

Vancouver: Copy

SHAFAATI A.R., CLARK B.J.. EVALUATION OF ACETONITRILE DEPROTEINISATION OF THE SERUM SAMPLES FOR THE ANALYSIS OF DRUGS IN SERUM USING CAPILLARY ZONE ELECTROPHORESIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2002;1(1):43-46. Available from: https://sid.ir/paper/286931/en

IEEE: Copy

A.R. SHAFAATI, and B.J. CLARK, “EVALUATION OF ACETONITRILE DEPROTEINISATION OF THE SERUM SAMPLES FOR THE ANALYSIS OF DRUGS IN SERUM USING CAPILLARY ZONE ELECTROPHORESIS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 1, no. 1, pp. 43–46, 2002, [Online]. Available: https://sid.ir/paper/286931/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops