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Information Journal Paper

Title

LECITHIN-STABILIZED MICROEMULSION: AN ORGANOGEL FOR TOPICAL APPLICATION OF KETOROLAC TROMETHAMINE. I: PHASE BEHAVIOR STUDIES

Pages

  59-63

Abstract

 The partial PHASE BEHAVIOR of systems composed of LECITHIN/isopropyl myristate (IPM) /water or KETOROLAC TROMETHAMINE (KT) solutions (2.5, 5, 10 and 50% w/w) at various LECITHIN/IPM weight ratios (km) have been investigated by the construction of PHASE DIAGRAMs. A commercially available soybean LECITHIN (namely, Epikuron 200, phosphatidylcholine purity greater than 95%) was used in this study. PHASE DIAGRAMs showed a narrow area of existence of a non-birefringent, transparent isotropic region along the LECITHIN / IPM axis in all systems, regardless of the km. The isotropic regions were stable for a minimum of 3 months at room temperature. The surfactant/oil ratio required for maximum KT incorporation has its minimum value in systems prepared with 50% KT solution, whereas the maximum value is obtained when a 2.5% KT solution was incorporated into the gel matrix. The results have also showed that for a given system, as km increases, the incorporation capacity increases. No significant differences in PHASE BEHAVIOR were noted when altering the concentration of KT solution from 2.5-10%. However, a small decrease in the extent of the gel region was observed when 50% drug solution was incorporated into the system.

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    APA: Copy

    ATTAR NASSERI, A., ZIA, H., NEEDHAM, T.E., & ABOU FAZELI, R.. (2003). LECITHIN-STABILIZED MICROEMULSION: AN ORGANOGEL FOR TOPICAL APPLICATION OF KETOROLAC TROMETHAMINE. I: PHASE BEHAVIOR STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 2(1), 59-63. SID. https://sid.ir/paper/286938/en

    Vancouver: Copy

    ATTAR NASSERI A., ZIA H., NEEDHAM T.E., ABOU FAZELI R.. LECITHIN-STABILIZED MICROEMULSION: AN ORGANOGEL FOR TOPICAL APPLICATION OF KETOROLAC TROMETHAMINE. I: PHASE BEHAVIOR STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2003;2(1):59-63. Available from: https://sid.ir/paper/286938/en

    IEEE: Copy

    A. ATTAR NASSERI, H. ZIA, T.E. NEEDHAM, and R. ABOU FAZELI, “LECITHIN-STABILIZED MICROEMULSION: AN ORGANOGEL FOR TOPICAL APPLICATION OF KETOROLAC TROMETHAMINE. I: PHASE BEHAVIOR STUDIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 2, no. 1, pp. 59–63, 2003, [Online]. Available: https://sid.ir/paper/286938/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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