SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOUSHDAR TEHRANI M.H.; FARNIA M.; SHALCHIAN NAZER M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2003 | Volume:2 | Issue:1 Page(s): 1-3

Download Full-Text

View:

679

Download:

309

Cites:

Information Journal Paper

Title

SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH

Author(s)

HOUSHDAR TEHRANI M.H. | FARNIA M. | SHALCHIAN NAZER M. | Issue Writer Certificate

Keywords

BACLOFEN

SYNTHESIS

GABA RECEPTOR

AGONIST

Abstract

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, BACLOFEN, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the SYNTHESIS of BACLOFEN. In this study an approach has been made to synthesize BACLOFEN in an alternative way. The key steps involved the condensation of p-chloro benzaldehyde with nitromethane and the reaction of b-nitro styrene thus prepared with malonate diethyl ester. Further reduction and decarboxylation of the product gave access to BACLOFEN with a good yield.

Cites

No record.

References

No record.

Cite

APA: Copy

HOUSHDAR TEHRANI, M.H., FARNIA, M., & SHALCHIAN NAZER , M.. (2003). SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 2(1), 1-3. SID. https://sid.ir/paper/286946/en

Vancouver: Copy

HOUSHDAR TEHRANI M.H., FARNIA M., SHALCHIAN NAZER M.. SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2003;2(1):1-3. Available from: https://sid.ir/paper/286946/en

IEEE: Copy

M.H. HOUSHDAR TEHRANI, M. FARNIA, and M. SHALCHIAN NAZER , “SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 2, no. 1, pp. 1–3, 2003, [Online]. Available: https://sid.ir/paper/286946/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops