SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH

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HOUSHDAR TEHRANI M.H.; FARNIA M.; SHALCHIAN NAZER M.

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2003 | Volume:2 | Issue:1 Page(s): 1-3

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Title

SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH

Author(s)

HOUSHDAR TEHRANI M.H. | FARNIA M. | SHALCHIAN NAZER M. | Issue Writer Certificate

Keywords

BACLOFEN

SYNTHESIS

GABA RECEPTOR

AGONIST

Abstract

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, BACLOFEN, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the SYNTHESIS of BACLOFEN. In this study an approach has been made to synthesize BACLOFEN in an alternative way. The key steps involved the condensation of p-chloro benzaldehyde with nitromethane and the reaction of b-nitro styrene thus prepared with malonate diethyl ester. Further reduction and decarboxylation of the product gave access to BACLOFEN with a good yield.

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APA: Copy

HOUSHDAR TEHRANI, M.H., FARNIA, M., & SHALCHIAN NAZER , M.. (2003). SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 2(1), 1-3. SID. https://sid.ir/paper/286946/en

Vancouver: Copy

HOUSHDAR TEHRANI M.H., FARNIA M., SHALCHIAN NAZER M.. SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2003;2(1):1-3. Available from: https://sid.ir/paper/286946/en

IEEE: Copy

M.H. HOUSHDAR TEHRANI, M. FARNIA, and M. SHALCHIAN NAZER , “SYNTHESIS OF BACLOFEN; AN ALTERNATIVE APPROACH,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 2, no. 1, pp. 1–3, 2003, [Online]. Available: https://sid.ir/paper/286946/en

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