RETINOL AND β-CAROTENE INHIBIT PTZ-INDUCED KINDLING IN MICE

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YOUSEFIPOUR M.; SAYAH M.; NARENJKAR J.

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Journal: Iranian Journal of Pharmaceutical Research Year:2004 | Volume:3 | Issue:Supplement 1 Page(s): 55-55

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Title

RETINOL AND β-CAROTENE INHIBIT PTZ-INDUCED KINDLING IN MICE

Author(s)

YOUSEFIPOUR M. | SAYAH M. | NARENJKAR J.

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Abstract

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, b-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and b-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect) and 2) attenuate the development of sensitization to convulsive and lethal effects of PTZ in kindled mice (anti-epileptogenic effect) when given as a pretreatment prior to each PTZ injection during kindling acquisition. Diazepam was used as positive control group. All these drugs showed anti-epileptogenic effects against PTZ-induced tonic seizures and lethality. Vitamin A and b-carotene had no effect on clonic seizures induced by PTZ in kindled mice. It can be concluded that vitamin A and b-carotene possess anti-epileptogenic activity. Retinoids appear to be valuable for development of a new class of anticonvulsant drugs.

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APA: Copy

YOUSEFIPOUR, M., NARENJKAR, J., & SAYAH, M.. (2004). RETINOL AND β-CAROTENE INHIBIT PTZ-INDUCED KINDLING IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 3(Supplement 1), 55-55. SID. https://sid.ir/paper/287160/en

Vancouver: Copy

YOUSEFIPOUR M., NARENJKAR J., SAYAH M.. RETINOL AND β-CAROTENE INHIBIT PTZ-INDUCED KINDLING IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2004;3(Supplement 1):55-55. Available from: https://sid.ir/paper/287160/en

IEEE: Copy

M. YOUSEFIPOUR, J. NARENJKAR, and M. SAYAH, “RETINOL AND β-CAROTENE INHIBIT PTZ-INDUCED KINDLING IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 3, no. Supplement 1, pp. 55–55, 2004, [Online]. Available: https://sid.ir/paper/287160/en

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