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Information Journal Paper

Title

RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RISPERIDONE IN HUMAN PLASMA

Pages

  37-40

Keywords

Abstract

 A simple, rapid and sensitive high-performance liquid chromatographic (HPLC) method for the determination of RISPERIDONE in human PLASMA was developed. An HPLC system based on a Nucleosil C8 column (150×4 mm) and a UV detector (l=280 nm) were used. A mixture of sodium dihydrogen phosphate buffer-acetonitrile (55:45, v/v) adjusted to pH 6.0 at a flow rate of 1.5 ml min-1 was used as mobile phase. The proteins were precipitated with an acetonitrile solution containing diltiazem as internal standard and the average recovery was 93.9±3.4 .The detection limit for RISPERIDONE in PLASMA was 0.5 ngml-1. The calibration curve was linear over the concentration range 2-50 ngml-1. The inter-day and intra-day assay coefficients of variation were found to be less than 5%. The present validated method was successfully used for pharmacokinetic studies of RISPERIDONE in human subjects.

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    APA: Copy

    FOROUTAN, S.M., ZARGHI, A., SHAFAATI, A.R., & KHODAM, A.. (2006). RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RISPERIDONE IN HUMAN PLASMA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 5(1), 37-40. SID. https://sid.ir/paper/287573/en

    Vancouver: Copy

    FOROUTAN S.M., ZARGHI A., SHAFAATI A.R., KHODAM A.. RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RISPERIDONE IN HUMAN PLASMA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2006;5(1):37-40. Available from: https://sid.ir/paper/287573/en

    IEEE: Copy

    S.M. FOROUTAN, A. ZARGHI, A.R. SHAFAATI, and A. KHODAM, “RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RISPERIDONE IN HUMAN PLASMA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 5, no. 1, pp. 37–40, 2006, [Online]. Available: https://sid.ir/paper/287573/en

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