PHARMACOLOGICAL EVIDENCES FOR THE ANTIAMNESIC EFFECTS OF DESMODIUM GANGETICUM IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HANUMANTHACHAR J.; MILIND P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2007 | Volume:6 | Issue:3 Page(s): 199-207

Download Full-Text

View:

429

Download:

289

Cites:

Information Journal Paper

Title

PHARMACOLOGICAL EVIDENCES FOR THE ANTIAMNESIC EFFECTS OF DESMODIUM GANGETICUM IN MICE

Author(s)

HANUMANTHACHAR J. | MILIND P. | Issue Writer Certificate

Keywords

ANTICHOLINESTERASE ACTIVITY

ACETYLCHOLINE

MEMORY

DESMODIUM GANGETICUM

Abstract

Dementia is one of the age related mental problems and a characteristic symptom of various neurodegenerative disorders including Alzheimer's disease. DESMODIUM GANGETICUM DC. (Leguminosae) is widely used in Ayurveda for treating various neurological disorders. In the present study, the effectiveness of aqueous extract of D. gangeticum in attenuating scopolamine-induced amnesia in mice was investigated. Passive avoidance paradigm was used to assess long-term MEMORY. In order to delineate the possible mechanism through which D. gangeticum elicits the anti-amnesic effects, we studied its influence on central cholinergic activity by estimating the ACETYLCHOLINE content of the whole brain and ACETYLCHOLINEsterase activity at different regions of the mouse brain, viz., cerebral cortex, midbrain, medulla oblongata and cerebellum. Pretreatment with D. gangeticum (100 mg/kg and 200 mg/kg, p.o.) for seven successive days, reversed scopolamine induced amnesia in mice. D. gangeticum increased mice brain ACETYLCHOLINE content and decreased acetyl cholinesterase activity in a similar manner to the standard cerebro-protective drug piracetam. Hence, aqueous extract of D. gangeticum can be used to delay the onset and reduce the severity of the symptoms of dementia and Alzheimer's disease.

Cites

No record.

References

No record.

Cite

APA: Copy

HANUMANTHACHAR, J., & MILIND, P.. (2007). PHARMACOLOGICAL EVIDENCES FOR THE ANTIAMNESIC EFFECTS OF DESMODIUM GANGETICUM IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 6(3), 199-207. SID. https://sid.ir/paper/287633/en

Vancouver: Copy

HANUMANTHACHAR J., MILIND P.. PHARMACOLOGICAL EVIDENCES FOR THE ANTIAMNESIC EFFECTS OF DESMODIUM GANGETICUM IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2007;6(3):199-207. Available from: https://sid.ir/paper/287633/en

IEEE: Copy

J. HANUMANTHACHAR, and P. MILIND, “PHARMACOLOGICAL EVIDENCES FOR THE ANTIAMNESIC EFFECTS OF DESMODIUM GANGETICUM IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 6, no. 3, pp. 199–207, 2007, [Online]. Available: https://sid.ir/paper/287633/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops