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Information Journal Paper

Title

SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF N-SUBSTITUTED IMIDAZOLE-5- CARBOXAMIDES IN FORCED SWIMMING TEST MODEL

Pages

  29-33

Abstract

 Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an ANTIDEPRESSANT. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles, So, N-[(4-morpholinyl) ethyl)]-I-benzyl-2-(alkylthio)- IH-imidazole-5-carboxamides (7a-c) were synthesized and studied for the ANTIDEPRESSANT activityusing forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively. 

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    APA: Copy

    HADI ZADEH, F., HOSSEINZADEH, HOSSEIN, MOTAMED SHARIATI, V.S., SEYFI, MAHMOUD, & KAZEMI, SHAHAB. (2008). SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF N-SUBSTITUTED IMIDAZOLE-5- CARBOXAMIDES IN FORCED SWIMMING TEST MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 7(1), 29-33. SID. https://sid.ir/paper/287648/en

    Vancouver: Copy

    HADI ZADEH F., HOSSEINZADEH HOSSEIN, MOTAMED SHARIATI V.S., SEYFI MAHMOUD, KAZEMI SHAHAB. SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF N-SUBSTITUTED IMIDAZOLE-5- CARBOXAMIDES IN FORCED SWIMMING TEST MODEL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2008;7(1):29-33. Available from: https://sid.ir/paper/287648/en

    IEEE: Copy

    F. HADI ZADEH, HOSSEIN HOSSEINZADEH, V.S. MOTAMED SHARIATI, MAHMOUD SEYFI, and SHAHAB KAZEMI, “SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF N-SUBSTITUTED IMIDAZOLE-5- CARBOXAMIDES IN FORCED SWIMMING TEST MODEL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 7, no. 1, pp. 29–33, 2008, [Online]. Available: https://sid.ir/paper/287648/en

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