مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

453
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

379
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF PHYLLANTHUS RHEEDII ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Pages

  53-59

Abstract

 The aim of this study was to investigate the effects of ethanolic extract of the whole plant of PHYLLANTHUS RHEEDII wight P.rheedii as ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC and ANTIOXIDANT effect in STREPTOZOTOCIN (STZ) induced diabetic rats. Male Wistar rats were administered P.rheedii (250 mg/kg) orally for 21 days and blood glucose level was measured weekly. At the end of 21 days, the serum lipid metabolites such as total cholesterol, triglycerides, high density lipoproteins (HDL) and protein metabolites such as total protein, albumin, globulin and albumin:globulin ratio (A:G) enzyme level viz serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) were determined. In order to determine ANTIOXIDANT activity of extract, liver tissues were homogenized in ice cold saline buffer and the assay of lipid peroxides (LPO), superoxide dismutase (SOD) and catalase (CAT) were performed in control, STZ and extract treated rats. All these effects were compared with glibenclamide as a reference antidiabetic drug. Oral administration of P.rheedii for 21 days resulted in a significant reduction in blood glucose level, lipid metabolism and enzymes level and significant improvement in LPO, SOD and catalase in liver tissues of STZ induced diabetic rats when compared with untreated diabetic rats. The protein metabolites were significantly altered near to normal. The effects produced by the extract were comparable to that of glibenclamide.In conclusion The P.rheedii showed significant ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC and ANTIOXIDANTs effect in STZ induced diabetic rats.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SIVAJOTHI, V., DEY, A., JAYAKARA, B., & RAJKAPOOR, B.. (2008). ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF PHYLLANTHUS RHEEDII ON STREPTOZOTOCIN INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 7(1), 53-59. SID. https://sid.ir/paper/287654/en

    Vancouver: Copy

    SIVAJOTHI V., DEY A., JAYAKARA B., RAJKAPOOR B.. ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF PHYLLANTHUS RHEEDII ON STREPTOZOTOCIN INDUCED DIABETIC RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2008;7(1):53-59. Available from: https://sid.ir/paper/287654/en

    IEEE: Copy

    V. SIVAJOTHI, A. DEY, B. JAYAKARA, and B. RAJKAPOOR, “ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECT OF PHYLLANTHUS RHEEDII ON STREPTOZOTOCIN INDUCED DIABETIC RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 7, no. 1, pp. 53–59, 2008, [Online]. Available: https://sid.ir/paper/287654/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button