FORMULATION AND OPTIMIZATION OF CAPTOPRIL SUBLINGUAL TABLET USING D-OPTIMAL DESIGN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BOLOURCHIAN N.; HADIDI N.; FOROUTAN S.M.; SHAFAGHI B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2008 | Volume:7 | Issue:4 Page(s): 259-267

Download Full-Text

View:

881

Download:

1,019

Cites:

Information Journal Paper

Title

FORMULATION AND OPTIMIZATION OF CAPTOPRIL SUBLINGUAL TABLET USING D-OPTIMAL DESIGN

Author(s)

BOLOURCHIAN N. | HADIDI N. | FOROUTAN S.M. | SHAFAGHI B. | Issue Writer Certificate

Keywords

CAPTOPRIL

SUBLINGUAL TABLET

D-OPTIMAL MIXTURE DESIGN

OPTIMIZATION

Abstract

The objective of the current study was to develop and optimize a SUBLINGUAL TABLET formulation of CAPTOPRIL which is an effective drug in the treatment of hypertension. CAPTOPRIL containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, talc and aspartame (fixed components). Tablets were evaluated for the physical properties including hardness, disintegration time and friability which were considered as responses in a D-optimal experimental plan. Results were statistically examined using special cubic model and polynomial mathematical equations and found to be statistically significant (p<0.05) for disintegration time and friability data. Meanwhile linear model was best fitted with hardness data. The obtained results were used to generate optimized overlay plot. The physical data from the numerical OPTIMIZATION were verified and found to be very close to those predicted from the regression analysis. Additional experiments including drug content, in vitro drug dissolution rate and accelerated stability studies were also performed on the optimum formulation. All results were in accordance with the requirements of a SUBLINGUAL TABLET.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

BOLOURCHIAN, N., HADIDI, N., FOROUTAN, S.M., & SHAFAGHI, B.. (2008). FORMULATION AND OPTIMIZATION OF CAPTOPRIL SUBLINGUAL TABLET USING D-OPTIMAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 7(4), 259-267. SID. https://sid.ir/paper/287694/en

Vancouver: Copy

BOLOURCHIAN N., HADIDI N., FOROUTAN S.M., SHAFAGHI B.. FORMULATION AND OPTIMIZATION OF CAPTOPRIL SUBLINGUAL TABLET USING D-OPTIMAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2008;7(4):259-267. Available from: https://sid.ir/paper/287694/en

IEEE: Copy

N. BOLOURCHIAN, N. HADIDI, S.M. FOROUTAN, and B. SHAFAGHI, “FORMULATION AND OPTIMIZATION OF CAPTOPRIL SUBLINGUAL TABLET USING D-OPTIMAL DESIGN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 7, no. 4, pp. 259–267, 2008, [Online]. Available: https://sid.ir/paper/287694/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops