STUDY ON CLOPIDOGREL IN INHIBITION OF PLATELET AGGREGATION IN SUSPECTED ANGINA PATIENTS, TREATED WITH A DAILY DOSE OF 75 MG OF CLOPIDOGREL FOR 7 DAYS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAN H.; JAN H.; HAFIZULLAH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2009 | Volume:8 | Issue:2 Page(s): 135-140

Download Full-Text

View:

313

Download:

105

Cites:

Information Journal Paper

Title

STUDY ON CLOPIDOGREL IN INHIBITION OF PLATELET AGGREGATION IN SUSPECTED ANGINA PATIENTS, TREATED WITH A DAILY DOSE OF 75 MG OF CLOPIDOGREL FOR 7 DAYS

Author(s)

KHAN H. | JAN H. | HAFIZULLAH M. | Issue Writer Certificate

Keywords

CLOPIDOGREL

CORONARY ARTERY DISEASE

PLATELET AGGREGATION

PESHAWAR

Abstract

This study was performed to assess the CLOPIDOGREL activity in inhibition of PLATELET AGGREGATION in suspected angina patients on a daily dosag of 75 mg of CLOPIDOGREL for at least 7 days.This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, PESHAWAR from 15th October 2007 to 20th December 2007. We included 105 suspected angina patients and measured their PLATELET AGGREGATION using the WBA aggregometer provided by the sponsoring pharmaceutical company. these patient were then given seven 75 mg CLOPIDOGREL tablets for one week for a once daily regimen and were asked to come for follow up after one week. Of 133 patients, 105 completed the follow up process and PLATELET AGGREGATION were measured. Both readings were noted on specially designed farms prepared in accordance with the objective of the study. Patients who were on any other anti-platelet like aspirin warfarine, heparin, etc were excluded from the study.A total of 105 patients with 28 males (52.83%) and 25 females (47.16%) were included in the study. According to age, the patients were in the range of 35 to 75 years with mean agebeing 55.79+8.74 years. Mean systolic blood pressure was 136.61+18.24 mmHg and mean diastolic blood pressure was 87.80+11.26 mmHg. Standard error of sampling for type A and type B drugs were 0.128 and 0.120, respectively. the PLATELET AGGREGATION readings after follow up were zero in 73 patients (69.52%), 1-3 ohms in 26 (24.76%), and 4-6 ohms in 6 (5.71%).As a whole, CLOPIDOGREL reduced the PLATELET AGGREGATION readings to below 3 ohms in 99/105 (94.28%), while in 6 (5.71%), there was some expected resistance to CLOPIDOGREL, and readings above 3 ohms were recorded. CLOPIDOGREL has a major role in inhibition of PLATELET AGGREGATION in patients with CAD. But, the activity of CLOPIDOGREL and the dose required to inhibit PLATELET AGGREGATION may depend upon the individuals. Resistance to CLOPIDOGREL, especially in low doses, is expected.

Cites

No record.

References

No record.

Cite

APA: Copy

KHAN, H., JAN, H., & HAFIZULLAH, M.. (2009). STUDY ON CLOPIDOGREL IN INHIBITION OF PLATELET AGGREGATION IN SUSPECTED ANGINA PATIENTS, TREATED WITH A DAILY DOSE OF 75 MG OF CLOPIDOGREL FOR 7 DAYS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 8(2), 135-140. SID. https://sid.ir/paper/287712/en

Vancouver: Copy

KHAN H., JAN H., HAFIZULLAH M.. STUDY ON CLOPIDOGREL IN INHIBITION OF PLATELET AGGREGATION IN SUSPECTED ANGINA PATIENTS, TREATED WITH A DAILY DOSE OF 75 MG OF CLOPIDOGREL FOR 7 DAYS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2009;8(2):135-140. Available from: https://sid.ir/paper/287712/en

IEEE: Copy

H. KHAN, H. JAN, and M. HAFIZULLAH, “STUDY ON CLOPIDOGREL IN INHIBITION OF PLATELET AGGREGATION IN SUSPECTED ANGINA PATIENTS, TREATED WITH A DAILY DOSE OF 75 MG OF CLOPIDOGREL FOR 7 DAYS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 8, no. 2, pp. 135–140, 2009, [Online]. Available: https://sid.ir/paper/287712/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops