PROTECTIVE EFFECT OF QUERCETIN ON OXIDATIVE STRESS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES IN VITRO

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JAMSHIDZADEH A.; REZAEIAN MEHRABADI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:2 Page(s): 169-175

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Information Journal Paper

Title

PROTECTIVE EFFECT OF QUERCETIN ON OXIDATIVE STRESS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES IN VITRO

Author(s)

JAMSHIDZADEH A. | REZAEIAN MEHRABADI A. | Issue Writer Certificate

Keywords

QUERCETIN

G6PD-DEFICIENCY

OXIDATIVE STRESS

OXYGEN-FREE RADICAL SCAVENGER

ERYTHROCYTES

VITAMIN C

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficient subjects are vulnerable to OXIDATIVE STRESS. QUERCETIN, a flavonoids, has been employed as a potent OXYGEN-FREE RADICAL SCAVENGER in order to assess the protective effects of QUERCETIN against H2O2-induced oxidative damage in G6PD-deficient and normal human ERYTHROCYTES. ERYTHROCYTES of G6PD-deficient (n = 10) and normal (n = 10) subjects were incubated with different concentrations of QUERCETIN. The produced thiobarbituric acid reactive substance (TBARS) and glutathione (GSH) level of ERYTHROCYTES were then subsequently measured.Different concentrations of QUERCETIN showed no significant hemolysis, compared with the phosphate buffer solution. Upon challenge with H2O2, there was a significant (p < 0.005) decrease in GSH and an increase in TBARS level in G6PD-deficient ERYTHROCYTES. With QUERCETIN, it managed to preserve concentrations of 15 to 75 mM preserved GSH and TBARS levels of normal and G6PD-deficient ERYTHROCYTES against H2O2-induced oxidative damage.In addition to its well-established antioxidant effects, QUERCETIN was also found to have cytoprotective properties.

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APA: Copy

JAMSHIDZADEH, A., & REZAEIAN MEHRABADI, A.. (2010). PROTECTIVE EFFECT OF QUERCETIN ON OXIDATIVE STRESS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES IN VITRO. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(2), 169-175. SID. https://sid.ir/paper/287746/en

Vancouver: Copy

JAMSHIDZADEH A., REZAEIAN MEHRABADI A.. PROTECTIVE EFFECT OF QUERCETIN ON OXIDATIVE STRESS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES IN VITRO. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(2):169-175. Available from: https://sid.ir/paper/287746/en

IEEE: Copy

A. JAMSHIDZADEH, and A. REZAEIAN MEHRABADI, “PROTECTIVE EFFECT OF QUERCETIN ON OXIDATIVE STRESS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES IN VITRO,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 2, pp. 169–175, 2010, [Online]. Available: https://sid.ir/paper/287746/en

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