HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RIVASTIG¬MINE IN HUMAN PLASMA FOR APPLICATION IN PHARMACOKINETIC STUDIES

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AMINI HOSSEIN; AHMADIANI A.A.H.

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:2 Page(s): 115-121

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Information Journal Paper

Title

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RIVASTIG¬MINE IN HUMAN PLASMA FOR APPLICATION IN PHARMACOKINETIC STUDIES

Author(s)

AMINI HOSSEIN | AHMADIANI A.A.H. | Issue Writer Certificate

Keywords

RIVASTIGMINE

LIQUID- LIQUIS EXTRACTION

HPLC

SPECTROPHOTOMETRIC DETECTION

PHARMACOKINETICS

Abstract

A simple and reproducible HPLC method with SPECTROPHOTOMETRIC DETECTION was developed for determination of RIVASTIGMINE in human plasma. Liquid-liquid extraction of RIVASTIGMINE and donepezil (as internal standard) from plasma samples was performed with 1-butanol/n-hexane (2:98 v/v) in alkaline condition followed by back-extraction into diluted acetic acid. Chromatography was carried out using a Silica column (250 mm × 4.6 mm, 5 mm) under isocratic elution with acetonitrile-50 mM aqueous sodium dihydrogen phosphate (17: 83 v/v, pH 3.1. Analyses were run at a flow-rate of 1.3 mL/min at of 50°C. The recovery was 90.8% and 95.7% for RIVASTIGMINE and the internal standard donepezil, respectively. The precision of the method was 2.6% to 9.1% over the concentration range of 0.5-16 ng/mL for RIVASTIGMINE in plasma with a linearity greater than 0.999. The method was specific and sensitive, with a quantification limit of 0.5 ng/mL and a detection limit of 0.2 ng/mL in plasma. The method was used for a bioequivalence study in healthy subjects.

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APA: Copy

AMINI, HOSSEIN, & AHMADIANI, A.A.H.. (2010). HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RIVASTIG¬MINE IN HUMAN PLASMA FOR APPLICATION IN PHARMACOKINETIC STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(2), 115-121. SID. https://sid.ir/paper/287747/en

Vancouver: Copy

AMINI HOSSEIN, AHMADIANI A.A.H.. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RIVASTIG¬MINE IN HUMAN PLASMA FOR APPLICATION IN PHARMACOKINETIC STUDIES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(2):115-121. Available from: https://sid.ir/paper/287747/en

IEEE: Copy

HOSSEIN AMINI, and A.A.H. AHMADIANI, “HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF RIVASTIG¬MINE IN HUMAN PLASMA FOR APPLICATION IN PHARMACOKINETIC STUDIES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 2, pp. 115–121, 2010, [Online]. Available: https://sid.ir/paper/287747/en

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