DEVELOPMENT OF OSMOTICALLY CONTROLLED MUCOADHESIVE CUP-CORE (OCMC) TABLET FOR THE ANTI-INFLAMMATORY ACTIVITY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

PATEL H.R.; PATEL M.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:1 Page(s): 21-26

Download Full-Text

View:

382

Download:

140

Cites:

Information Journal Paper

Title

DEVELOPMENT OF OSMOTICALLY CONTROLLED MUCOADHESIVE CUP-CORE (OCMC) TABLET FOR THE ANTI-INFLAMMATORY ACTIVITY

Author(s)

PATEL H.R. | PATEL M.M. | Issue Writer Certificate

Keywords

OSMOTIC CUP-CORE TABLET

ACECLOFENAC

MUCOADHESION

DRUG RELEASE

ANTI- INFLAMMATORY ACTIVITY

Abstract

The aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (OCMC) containing ACECLOFENAC. A special technique was used while preparing an OCMC. Stability of OCMC was determined in natural human saliva, and it was found that both pH and device are stable in human saliva. OCMC was evaluated by weight uniformity, thickness, hardness, friability, swelling, mucoadhesive strength and in vitro DRUG RELEASE. Swelling index was higher with formulations containing hydroxypropyl methylcellulose (HPMC) K4M alone, and it decreases with its decreasing concentration in the OCMC. The in vitro DRUG RELEASE studies showed a release with the composition of formulation up to 12 h. The mechanism of DRUG RELEASE was found to be zero order kinetics with diffusion controlled DRUG RELEASE. It has shown significant anti-inflammatory activity (P<0.001) and no hypersensitive reaction. It can be concluded that by changing the content of OCMC system, a desire effect is generated and it overcomes the drawback associated with the conventional buccal adhesive tablet.

Cites

No record.

References

No record.

Cite

APA: Copy

PATEL, H.R., & PATEL, M.M.. (2010). DEVELOPMENT OF OSMOTICALLY CONTROLLED MUCOADHESIVE CUP-CORE (OCMC) TABLET FOR THE ANTI-INFLAMMATORY ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(1), 21-26. SID. https://sid.ir/paper/287773/en

Vancouver: Copy

PATEL H.R., PATEL M.M.. DEVELOPMENT OF OSMOTICALLY CONTROLLED MUCOADHESIVE CUP-CORE (OCMC) TABLET FOR THE ANTI-INFLAMMATORY ACTIVITY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(1):21-26. Available from: https://sid.ir/paper/287773/en

IEEE: Copy

H.R. PATEL, and M.M. PATEL, “DEVELOPMENT OF OSMOTICALLY CONTROLLED MUCOADHESIVE CUP-CORE (OCMC) TABLET FOR THE ANTI-INFLAMMATORY ACTIVITY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 1, pp. 21–26, 2010, [Online]. Available: https://sid.ir/paper/287773/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops