FORMULATION AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF OLANZAPINE-2-HYDROXYPROPYL-β-CYCLODEXTRIN INCLUSION COMPLEX

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHANKARRAO KULKARNI AJIT; MAHADEO GHADGE DHAIRYSHEEL; BALAVANTRAO KOKATE PANKAJ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:4 Page(s): 335-347

Download Full-Text

View:

370

Download:

191

Cites:

Information Journal Paper

Title

FORMULATION AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF OLANZAPINE-2-HYDROXYPROPYL-β-CYCLODEXTRIN INCLUSION COMPLEX

Author(s)

SHANKARRAO KULKARNI AJIT | MAHADEO GHADGE DHAIRYSHEEL | BALAVANTRAO KOKATE PANKAJ | Issue Writer Certificate

Keywords

ORALLY DISINTEGRATING TABLETS

OLANZAPINE

OLANZAPINE-2-HYDROXYPROPYL-β- CYCLODEXTRIN INCLUSION COMPLEX

PHASE SOLUBILITY ANALYSIS

Abstract

The aim of this study was to design ORALLY DISINTEGRATING TABLETS of OLANZAPINE and to complexOlanzapine with 2-hydroxypropyl-b-cyclodextrin with special emphasis on disintegration and dissolution studies. Phase solubility studies demonstrated the formation of 1:1 molar inclusion complex by kneading method. Tablets were prepared by using superdisintegrants namely, sodium starch glycolate, croscarmellose sodium, crospovidone, tulsion 339, and indion 414. Complex was characterized using infrared spectroscopy, drug content estimation, saturated solubility study, diffrerential scanning calorimetry and X-ray diffractometry.5% w/w croscarmellose sodium showed the minimum disintegration time 39 ± 1.76 sec and in-vitro drug release 99.19 ± 0.18% within 6 min. In general, solubility of OLANZAPINE can be improved by complexing with 2-hydroxypropyl-b- cyclodextrin. Croscarmellose sodium can be used for faster disintegration of tablets.

Cites

No record.

References

No record.

Cite

APA: Copy

SHANKARRAO, KULKARNI AJIT, MAHADEO, GHADGE DHAIRYSHEEL, & BALAVANTRAO, KOKATE PANKAJ. (2010). FORMULATION AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF OLANZAPINE-2-HYDROXYPROPYL-β-CYCLODEXTRIN INCLUSION COMPLEX. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(4), 335-347. SID. https://sid.ir/paper/287821/en

Vancouver: Copy

SHANKARRAO KULKARNI AJIT, MAHADEO GHADGE DHAIRYSHEEL, BALAVANTRAO KOKATE PANKAJ. FORMULATION AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF OLANZAPINE-2-HYDROXYPROPYL-β-CYCLODEXTRIN INCLUSION COMPLEX. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(4):335-347. Available from: https://sid.ir/paper/287821/en

IEEE: Copy

KULKARNI AJIT SHANKARRAO, GHADGE DHAIRYSHEEL MAHADEO, and KOKATE PANKAJ BALAVANTRAO, “FORMULATION AND IN-VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF OLANZAPINE-2-HYDROXYPROPYL-β-CYCLODEXTRIN INCLUSION COMPLEX,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 4, pp. 335–347, 2010, [Online]. Available: https://sid.ir/paper/287821/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops