PREPARATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE PLGA MICROPARTICLES CONTAINING TRIPTORELINE

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MAHBOUBIAN ALIREZA; HASHEMEIN SEYYED KAZEM; MOGHADAM SHADI; ATYABI FATEMEH; DINARVAND RASSOUL

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2010 | Volume:9 | Issue:4 Page(s): 369-378

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Title

PREPARATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE PLGA MICROPARTICLES CONTAINING TRIPTORELINE

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Keywords

MICROSPHERE

TRIPTORELINE

DOUBLE EMULSION

CONTROLLED-RELEASE

PLGA

Abstract

Triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Frequent injection of drug decreases patients’ compliance. The present study describes the formulation of a sustained release microparticulate drug delivery system containing TRIPTORELINE acetate, using poly (D, L lactide-co-glycolide) (PLGA). Biodegradable MICROSPHEREs were prepared using 50 : 50 PLGA by a water in-oil-in-water (w/o/w) DOUBLE EMULSION-solvent evaporation procedure and characterized for drug content and drug release rate using the a HPLC method, particle size distribution using the laser diffraction method, and surface morphology using scanning electron microscopy and drug release rate. Effect of critical process parameters and formulation variables; i.e.volume of inner water phase, addition of NaCl to the outer aqueous phase (W2), addition of different types and amounts of emulsifying agents on MICROSPHERE characteristics; were investigated. MICROSPHEREs prepared were spherical with a smooth surface, but addition of poloxamer to the first emulsion produced MICROSPHEREs with large pores. Size of microparticles was dependent on the type, as well as the amount of co-encapsulated surfactants. Increasing the inner water phase volume resulted in larger particles with a lower encapsulation efficiency. Low concentrations of Span 20 decreased TRIPTORELINE release rate, whereas the addition of poloxamer or high concentrations of Span 20 increased the drug release rateit. In conclusion, by selecting an appropriate level of the investigated parameters, spherical microparticles with encapsulation efficiencies higher than 90% and a prolonged TRIPTORELINE release over 45 days were obtained.

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APA: Copy

MAHBOUBIAN, ALIREZA, HASHEMEIN, SEYYED KAZEM, MOGHADAM, SHADI, ATYABI, FATEMEH, & DINARVAND, RASSOUL. (2010). PREPARATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE PLGA MICROPARTICLES CONTAINING TRIPTORELINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 9(4), 369-378. SID. https://sid.ir/paper/287826/en

Vancouver: Copy

MAHBOUBIAN ALIREZA, HASHEMEIN SEYYED KAZEM, MOGHADAM SHADI, ATYABI FATEMEH, DINARVAND RASSOUL. PREPARATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE PLGA MICROPARTICLES CONTAINING TRIPTORELINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2010;9(4):369-378. Available from: https://sid.ir/paper/287826/en

IEEE: Copy

ALIREZA MAHBOUBIAN, SEYYED KAZEM HASHEMEIN, SHADI MOGHADAM, FATEMEH ATYABI, and RASSOUL DINARVAND, “PREPARATION AND IN-VITRO EVALUATION OF CONTROLLED RELEASE PLGA MICROPARTICLES CONTAINING TRIPTORELINE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 9, no. 4, pp. 369–378, 2010, [Online]. Available: https://sid.ir/paper/287826/en

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