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Information Journal Paper

Title

CYTOTOXIC EFFECT OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROIMIDAZOLE MOIETY

Pages

  497-503

Abstract

 The 1, 4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant CYTOTOXICITY. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic CYTOTOXICITY of some derivatives of DHP containing NITROIMIDAZOLE moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in CYTOTOXICITY; Ca2+ channels.

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    APA: Copy

    MIRI, RAMIN, JAVIDNIA, KATAYOUN, AMIRGHOFRAN, ZAHRA, SALIMI, SEYYED HOSSEIN, SABETGHADAM, ZAHRA, MEILI, SAVIS, & MEHDIPOUR, AHMAD REZA. (2011). CYTOTOXIC EFFECT OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROIMIDAZOLE MOIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 497-503. SID. https://sid.ir/paper/287840/en

    Vancouver: Copy

    MIRI RAMIN, JAVIDNIA KATAYOUN, AMIRGHOFRAN ZAHRA, SALIMI SEYYED HOSSEIN, SABETGHADAM ZAHRA, MEILI SAVIS, MEHDIPOUR AHMAD REZA. CYTOTOXIC EFFECT OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROIMIDAZOLE MOIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):497-503. Available from: https://sid.ir/paper/287840/en

    IEEE: Copy

    RAMIN MIRI, KATAYOUN JAVIDNIA, ZAHRA AMIRGHOFRAN, SEYYED HOSSEIN SALIMI, ZAHRA SABETGHADAM, SAVIS MEILI, and AHMAD REZA MEHDIPOUR, “CYTOTOXIC EFFECT OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES CONTAINING NITROIMIDAZOLE MOIETY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 497–503, 2011, [Online]. Available: https://sid.ir/paper/287840/en

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