ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY ACTIVITIES OF A BIOACTIVE ALKALOID FROM THE ROOT BARK OF PLUMERIA ACUTIFOLIA POIR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALAKSHMI VIJAY; CHANDIRAN RAVI; VELRAJ MALARKODI; JAYAKUMARI HEMALATHA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:3 Page(s): 525-533

Download Full-Text

View:

321

Download:

Cites:

Information Journal Paper

Title

ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY ACTIVITIES OF A BIOACTIVE ALKALOID FROM THE ROOT BARK OF PLUMERIA ACUTIFOLIA POIR

Author(s)

ALAKSHMI VIJAY | CHANDIRAN RAVI | VELRAJ MALARKODI | JAYAKUMARI HEMALATHA | Issue Writer Certificate

Keywords

PLUMERIA ACUTIFOLIA

PLUMERIANINE

ANTI-ANAPHYLACTIC

ANTI-INFLAMMATORY

BIOACTIVE ALKALOID

Abstract

In the present study, ANTI-ANAPHYLACTIC, ANTI-INFLAMMATORY and membrane stabilizing properties of a lupine alkaloid PLUMERIANINE (compound 1), isolated from the root bark of PLUMERIA ACUTIFOLIA Poir were investigated in animal models. The ANTI-ANAPHYLACTIC activity of compound 1 (10, 25 and 50 mg/Kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and also investigated for its ANTI-INFLAMMATORY activity against the carrageenin induced paw edema and cotton pellet granuloma in albino rats. A dosedependent beneficial effect was observed on the leakage of Evans Blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum. The compound 1 also exhibited a significant (p<0.01) inhibition of rat paw edema and granuloma tissue formation, including significant protection of RBC against the hemolytic effect of hypotonic solution, an indication of membrane-stabilizing activity. ANTI-ANAPHYLACTIC activity of compound 1 may be possibly due to the inhibition of releasing various inflammatory mediators. ANTI-INFLAMMATORY activity of compound 1 may be related to the inhibition of the early phase and late phase of inflammatory events.

Cites

No record.

References

No record.

Cite

APA: Copy

ALAKSHMI, VIJAY, CHANDIRAN, RAVI, VELRAJ, MALARKODI, & JAYAKUMARI, HEMALATHA. (2011). ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY ACTIVITIES OF A BIOACTIVE ALKALOID FROM THE ROOT BARK OF PLUMERIA ACUTIFOLIA POIR. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 525-533. SID. https://sid.ir/paper/287843/en

Vancouver: Copy

ALAKSHMI VIJAY, CHANDIRAN RAVI, VELRAJ MALARKODI, JAYAKUMARI HEMALATHA. ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY ACTIVITIES OF A BIOACTIVE ALKALOID FROM THE ROOT BARK OF PLUMERIA ACUTIFOLIA POIR. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):525-533. Available from: https://sid.ir/paper/287843/en

IEEE: Copy

VIJAY ALAKSHMI, RAVI CHANDIRAN, MALARKODI VELRAJ, and HEMALATHA JAYAKUMARI, “ANTI-ANAPHYLACTIC AND ANTI-INFLAMMATORY ACTIVITIES OF A BIOACTIVE ALKALOID FROM THE ROOT BARK OF PLUMERIA ACUTIFOLIA POIR,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 525–533, 2011, [Online]. Available: https://sid.ir/paper/287843/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops