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1

Information Journal Paper

Title

PLACE AVERSION BY MORPHINE IN OFFSPRING BORN OF FEMALE MORPHINE ADMINISTERED WISTAR RATS

Pages

  577-584

Keywords

OFFSPRING (RAT) 

Abstract

 This research was designed to study sexual differences in PLACE CONDITIONING induced by MORPHINE in offspring born of female Wistar rats mated with drug-naïve males. Mothers were exposed to MORPHINE during the 14th-16th days of gestational. Control dams were simply saline-injected. Female and male virgin offspring born of MORPHINE-treated or saline-treated mothers were separately housed until become fully matured. A 3-day schedule of an unbiased conditioning procedure was used to the induce conditioning to MORPHINE (2.5-7.5 mg/Kg, SC) in the offspring. According to the results, female offspring born of saline-administered mothers were MORPHINE place-conditioned at lower doses of opioid (2.5 mg/Kg) in comparison to the males. An increase in locomotor activity in the females at 7.5 mg/Kg of opioid was also revealed. In contrast, administration of MORPHINE (2.5-7.5 mg/Kg, SC), induced a significant AVERSION in either sexes of offspring born of MORPHINE-exposed mothers. Moreover, female offspring of this category acquired more pronounced AVERSION at higher doses of MORPHINE than males. In addition, a significant MORPHINE-dose effect (7.5 mg/Kg, SC) on locomotor activity of these females’ offspring was observed. This study may highlight sex differences in conditioning effects induced by MORPHINE between offspring derived of MORPHINE-treated mothers and those of saline-treated.

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    • Cite

    APA: Copy

    KARAMI, MANIZHEH, & ZARRINDAST, MOHAMMAD REZA. (2011). PLACE AVERSION BY MORPHINE IN OFFSPRING BORN OF FEMALE MORPHINE ADMINISTERED WISTAR RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 577-584. SID. https://sid.ir/paper/287850/en

    Vancouver: Copy

    KARAMI MANIZHEH, ZARRINDAST MOHAMMAD REZA. PLACE AVERSION BY MORPHINE IN OFFSPRING BORN OF FEMALE MORPHINE ADMINISTERED WISTAR RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):577-584. Available from: https://sid.ir/paper/287850/en

    IEEE: Copy

    MANIZHEH KARAMI, and MOHAMMAD REZA ZARRINDAST, “PLACE AVERSION BY MORPHINE IN OFFSPRING BORN OF FEMALE MORPHINE ADMINISTERED WISTAR RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 577–584, 2011, [Online]. Available: https://sid.ir/paper/287850/en

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