مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

280
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

180
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

EFFECT OF FLUVOXAMINE ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS EVALUATION OF THE ACTION SITES

Pages

  611-618

Abstract

 The present study was designed to explore the anti-inflammatory effect of FLUVOXAMINE, as a selective serotonin reuptake inhibitor (SSRI) anti-depressant, on CARRAGEENAN-induced paw edema in more details. At first, FLUVOXAMINE was administered intra-peritoneally (2.5, 12.5, 25 and 50 mg Kg-1) 30 min before the subplantar injection of CARRAGEENAN. FLUVOXAMINE was also injected intra-peritoneally at a dose of 50 mg Kg-1 30 or 90 min after CARRAGEENAN injection. Then, FLUVOXAMINE was given INTRA-CEREBROVENTRICULARly (25, 50 and 100 mg/rat) and intrathecally (25, 50 and 100 mg/rat) 30 min before the CARRAGEENAN challenge. Finally, the effect of MIFEPRISTONE (5 mg Kg-1), an antagonist of the glucocorticoid receptor, on the anti-edema effect of FLUVOXAMINE (50 mg Kg-1) was investigated. Results showed that intra-peritoneal (IP) administration of FLUVOXAMINE before or after CARRAGEENAN injection considerably inhibited paw edema response at 4 h post-CARRAGEENAN (p<0.001), but INTRA-CEREBROVENTRICULAR (i.c.v.) and INTRA-THECAL (i.t.) injection of FLUVOXAMINE did not alter the degree of paw swelling. The inhibitory effect of FLUVOXAMINE was reduced by the pretreatment of MIFEPRISTONE (p<0.01).Our results suggest that IP administration of FLUVOXAMINE produces a noticeable antiinflammatory effect in the CARRAGEENAN-induced paw edema in RATs and at least, a part of this effect is mediated through glucocorticoid receptor. Moreover, it seems unlikely that central sites have an important role in this inhibitory effect of FLUVOXAMINE.

Cites

  • No record.
  • References

  • No record.
  • Cite

    APA: Copy

    HAJHASHEMI, VALIOLLAH, SADEGHI, HOSSEIN, MINAIYAN, MOHSEN, MOVAHEDIAN, AHMAD, & TALEBI, ARDESHIR. (2011). EFFECT OF FLUVOXAMINE ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS EVALUATION OF THE ACTION SITES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 611-618. SID. https://sid.ir/paper/287861/en

    Vancouver: Copy

    HAJHASHEMI VALIOLLAH, SADEGHI HOSSEIN, MINAIYAN MOHSEN, MOVAHEDIAN AHMAD, TALEBI ARDESHIR. EFFECT OF FLUVOXAMINE ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS EVALUATION OF THE ACTION SITES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):611-618. Available from: https://sid.ir/paper/287861/en

    IEEE: Copy

    VALIOLLAH HAJHASHEMI, HOSSEIN SADEGHI, MOHSEN MINAIYAN, AHMAD MOVAHEDIAN, and ARDESHIR TALEBI, “EFFECT OF FLUVOXAMINE ON CARRAGEENAN-INDUCED PAW EDEMA IN RATS EVALUATION OF THE ACTION SITES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 611–618, 2011, [Online]. Available: https://sid.ir/paper/287861/en

    Related Journal Papers

  • No record.
  • Related Seminar Papers

  • No record.
  • Related Plans

  • No record.
  • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button