PREPARATION AND DETERMINATION OF DRUG-POLYMER INTERACTION AND IN-VITRO RELEASE OF MEFENAMIC ACID MICROSPHERES MADE OF CELLULOSE ACETATE PHTHALATE AND/OR ETHYLCELLULOSE POLYMERS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JELVEHGARI MITRA; HASSANZADEH DAVOUD; KIAFAR FARHAD; LOVEYMI BADIR DELF; AMIRI SARA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:3 Page(s): 457-467

Download Full-Text

View:

352

Download:

155

Cites:

Information Journal Paper

Title

PREPARATION AND DETERMINATION OF DRUG-POLYMER INTERACTION AND IN-VITRO RELEASE OF MEFENAMIC ACID MICROSPHERES MADE OF CELLULOSE ACETATE PHTHALATE AND/OR ETHYLCELLULOSE POLYMERS

Author(s)

Keywords

MEFENAMIC ACID

ETHYLCELLULOSE

CELLULOSE ACETATE PHTHALATE

MICROPARTICLES

MODIFIED EMULSION-SOLVENT EVAPORATION

Abstract

The objective of this study was to formulate and evaluate the drug-polymer interaction of MEFENAMIC ACID (MA) using two polymers with different characteristics as ETHYLCELLULOSE (EC) and/or CELLULOSE ACETATE PHTHALATE (CAP). Microspheres were prepared by the modified emulsion solvent evaporation (MESE). The effect of drug-polymer interaction was studied for each of microspheres. Important parameters in the evaluation of a microencapsulation technique are encapsulation efficiency, yield production, particle size, surface characteristics of microspheres, scanning electronic microscopy (SEM), powder X-ray diffraction analysis (XRD), and differential scanning calorimetry (DSC). The in-vitro release studies are performed in Tris buffer (pH 9) with Sodium lauryl sulfate (SLS). Microspheres containing CAP and EC showed 68-97% and 63-76% of entrapment efficiency, respectively. The thermogram X-ray and DSC showed stable character of MA in the microspheres and revealed an absence of drug polymer interaction. The prepared microspheres were spherical in shape and had a size range of 235-436 mm for CAP-microspheres and 358-442 mm for EC-microspheres. The results suggest that MA was successfully and efficiently encapsulated; the release rates of matrix microspheres are related to the type of polymer, only when polymers (EC and CAP combine with 1: 1 ratio) were used to get prolonged drug release with reducing the polymers content in the microspheres. Data obtained from in-vitro release for microspheres and commercial capsule were fitted to various kinetic models and the high correlation was obtained in the peppas model.

Cites

No record.

References

No record.

Cite

APA: Copy

JELVEHGARI, MITRA, HASSANZADEH, DAVOUD, KIAFAR, FARHAD, LOVEYMI, BADIR DELF, & AMIRI, SARA. (2011). PREPARATION AND DETERMINATION OF DRUG-POLYMER INTERACTION AND IN-VITRO RELEASE OF MEFENAMIC ACID MICROSPHERES MADE OF CELLULOSE ACETATE PHTHALATE AND/OR ETHYLCELLULOSE POLYMERS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(3), 457-467. SID. https://sid.ir/paper/287862/en

Vancouver: Copy

JELVEHGARI MITRA, HASSANZADEH DAVOUD, KIAFAR FARHAD, LOVEYMI BADIR DELF, AMIRI SARA. PREPARATION AND DETERMINATION OF DRUG-POLYMER INTERACTION AND IN-VITRO RELEASE OF MEFENAMIC ACID MICROSPHERES MADE OF CELLULOSE ACETATE PHTHALATE AND/OR ETHYLCELLULOSE POLYMERS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(3):457-467. Available from: https://sid.ir/paper/287862/en

IEEE: Copy

MITRA JELVEHGARI, DAVOUD HASSANZADEH, FARHAD KIAFAR, BADIR DELF LOVEYMI, and SARA AMIRI, “PREPARATION AND DETERMINATION OF DRUG-POLYMER INTERACTION AND IN-VITRO RELEASE OF MEFENAMIC ACID MICROSPHERES MADE OF CELLULOSE ACETATE PHTHALATE AND/OR ETHYLCELLULOSE POLYMERS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 3, pp. 457–467, 2011, [Online]. Available: https://sid.ir/paper/287862/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops