SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANALGESIC ACTIVITY OF 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINES

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SAWANT RAMESH; SARODE VARSHA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2011 | Volume:10 | Issue:4 Page(s): 733-739

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Information Journal Paper

Title

SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANALGESIC ACTIVITY OF 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINES

Author(s)

SAWANT RAMESH | SARODE VARSHA | Issue Writer Certificate

Keywords

2-METHYLTHIO-1

4-DIHYDROPYRIMIDINE

BIGINELLI REACTION

SYNTHESIS

ANALGESIC

Abstract

A series of 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINE derivatives (II) were synthesized in good yields by alkylation of 1, 2, 3, 4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were confirmed by elemental analysis, IR and 1H NMR spectra. The compounds were tested for ANALGESIC activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl showed excellent to good ANALGESIC activity. Other compounds showed moderate ANALGESIC activity. The observed ANALGESIC activity is mainly because of inhibition of the peripheral pain mechanism by the title compounds.

Cites

GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES

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APA: Copy

SAWANT, RAMESH, & SARODE, VARSHA. (2011). SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANALGESIC ACTIVITY OF 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 10(4), 733-739. SID. https://sid.ir/paper/287882/en

Vancouver: Copy

SAWANT RAMESH, SARODE VARSHA. SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANALGESIC ACTIVITY OF 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2011;10(4):733-739. Available from: https://sid.ir/paper/287882/en

IEEE: Copy

RAMESH SAWANT, and VARSHA SARODE, “SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANALGESIC ACTIVITY OF 2-METHYLTHIO-1, 4-DIHYDROPYRIMIDINES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 10, no. 4, pp. 733–739, 2011, [Online]. Available: https://sid.ir/paper/287882/en

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