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Information Journal Paper

Title

GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES

Pages

  1105-1114

Keywords

SBA-PR-SO3H 
MULTICOMPONENT REACTION (MCR) 

Abstract

 Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) with pore size 6 nm as an efficient heterogeneous nanoporous solid acid catalyst exhibited good catalytic activity in the Biginellilike reaction in the synthesis of spiroheterobicyclic rings with good yield and good recyclability. Spiro-pyrimidinethiones/spiro-pyrimidinones-barbituric acid derivatives were synthesized in a simple and efficient method using the one-pot three-component reaction of a cyclic 1,3- dicarbonyl compounds (barbituric acid), an aromatic aldehyde and urea or thiourea in the presence of nanoporous silica SBA-Pr-SO3H under solvent free conditions. UREASE INHIBITORY activity of spiro compounds were tested against Jack bean urease using Berthelot alkaline phenol–hypochlorite method. Five of 13 compounds were inhibitor and two of them were enzyme activators. Analysis of the docking results showed that, in most of the spiro molecules, one of the carbonyl groups is coordinated with both nickel atoms, while the other one is involved in the formation of hydrogen bonds with important active-site residues. The effect of inserting two methyl groups on N atoms of barbiturate ring, S substituted, ortho, meta and para substituted compounds were investigated too.

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    Cite

    APA: Copy

    MOHAMMADI ZIARANIA, GHODSI, ASADIA, SHIMA, FARAMARZI, SAKINEH, & AMANLOU, MASSOUD. (2015). GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1105-1114. SID. https://sid.ir/paper/288409/en

    Vancouver: Copy

    MOHAMMADI ZIARANIA GHODSI, ASADIA SHIMA, FARAMARZI SAKINEH, AMANLOU MASSOUD. GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1105-1114. Available from: https://sid.ir/paper/288409/en

    IEEE: Copy

    GHODSI MOHAMMADI ZIARANIA, SHIMA ASADIA, SAKINEH FARAMARZI, and MASSOUD AMANLOU, “GREEN SYNTHESIS AND UREASE INHIBITORY ACTIVITY OF SPIRO-PYRIMIDINETHIONES/SPIRO-PYRIMIDINONES-BARBITURIC ACID DERIVATIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1105–1114, 2015, [Online]. Available: https://sid.ir/paper/288409/en

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