SYNTHESIS AND EVALUATION OF THE ANXIOLYTIC ACTIVITY OF SOME PHTHALIMIDE DERIVATIVES IN MICE MODEL OF ANXIETY

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HASSANZADEH FARSHID; RABBANI MOHAMMAD; KHODARAHMI GHADAM ALI; MOOSAVI MEHRNOOSH

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Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 109-115

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Title

SYNTHESIS AND EVALUATION OF THE ANXIOLYTIC ACTIVITY OF SOME PHTHALIMIDE DERIVATIVES IN MICE MODEL OF ANXIETY

Author(s)

HASSANZADEH FARSHID | RABBANI MOHAMMAD | KHODARAHMI GHADAM ALI | MOOSAVI MEHRNOOSH | Issue Writer Certificate

Keywords

PHTHALIMIDE

3-NITROPHTHALIMIDE

ELEVATED PLUS-MAZE

ANXIETY

Abstract

The aim of the present study was to synthesis a series of PHTHALIMIDEs based on our previous works and examine their anxiolytic properties. Using a three steps process, PHTHALIMIDEs were prepared from the corresponding di-methyl phthalate derivatives. Phthalic anhydride was nitrated to produce 3-nitrophthalic acid. Ring closer of either 3-nitrophthalic acid or di-methyl phthalate with urea were carried out in reflux condition. Final compounds were prepared by base catalyzed condensation of 4-methylbenzoyl chloride, benzoyl chloride and benzyl chloride with the resulting imides. From the tested compounds, onlyN- benzoyl 3-nitro-PHTHALIMIDE was shown to produce anxiolytic activity by increasing the number of entries and time spent in open arms at 10 mg/kg.

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APA: Copy

HASSANZADEH, FARSHID, RABBANI, MOHAMMAD, KHODARAHMI, GHADAM ALI, & MOOSAVI, MEHRNOOSH. (2012). SYNTHESIS AND EVALUATION OF THE ANXIOLYTIC ACTIVITY OF SOME PHTHALIMIDE DERIVATIVES IN MICE MODEL OF ANXIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 109-115. SID. https://sid.ir/paper/287899/en

Vancouver: Copy

HASSANZADEH FARSHID, RABBANI MOHAMMAD, KHODARAHMI GHADAM ALI, MOOSAVI MEHRNOOSH. SYNTHESIS AND EVALUATION OF THE ANXIOLYTIC ACTIVITY OF SOME PHTHALIMIDE DERIVATIVES IN MICE MODEL OF ANXIETY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):109-115. Available from: https://sid.ir/paper/287899/en

IEEE: Copy

FARSHID HASSANZADEH, MOHAMMAD RABBANI, GHADAM ALI KHODARAHMI, and MEHRNOOSH MOOSAVI, “SYNTHESIS AND EVALUATION OF THE ANXIOLYTIC ACTIVITY OF SOME PHTHALIMIDE DERIVATIVES IN MICE MODEL OF ANXIETY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 109–115, 2012, [Online]. Available: https://sid.ir/paper/287899/en

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