THE RATE OF ANTIBIOTIC DOSAGE ADJUSTMENT IN RENAL DYSFUNCTION

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FAHIMI FANAK; EMAMI SEPIDEH; RASHID FAROKHI FARIN

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 157-161

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Information Journal Paper

Title

THE RATE OF ANTIBIOTIC DOSAGE ADJUSTMENT IN RENAL DYSFUNCTION

Author(s)

FAHIMI FANAK | EMAMI SEPIDEH | RASHID FAROKHI FARIN | Issue Writer Certificate

Keywords

RENAL DYSFUNCTION

DOSAGE ADJUSTMENT

CREATININE CLEARANCE

COCKCROFT AND GAULT

MDRD

Abstract

The purpose of this study was to determine the number of prescribed antibiotics being appropriately adjusted and to assess antibiotics with the highest incorrect dosing based on the patient’s renal function according to distinguished guidelines.The study was conducted at a 446-bed university hospital. One hundred and fifty patientsadmitted through different wards of the hospital were included in the study. Demographic data were extracted and CREATININE CLEARANCE was calculated using either Cockcroft-Gault (C&G) or Modification of Diet in Renal Disease (MDRD) formula. In patients with CREATININE CLEARANCEs less than 50 mL/min, antibiotic dosages were compared with guideline dose recommendations to judge whether they were correctly adjusted.Two hundreds and ninety-one instructions (79.9%) of 364 antibiotic prescriptions required DOSAGE ADJUSTMENT based on the patient’s renal condition. These adjustments were rationally performed in 43.7% and 61.4% of prescriptions, according to the two guidelines used.Ciprofloxacin (29.1% of cases), and vancomycin (33.6% of cases), were the most inappropriate prescribed antibiotics in terms of dose administration.Drug dosing adjustments should be emphasized in patients with RENAL DYSFUNCTION. Failure to do so may lead to higher morbidity and mortality as well as therapeutic costs. Estimating CREATININE CLEARANCE prior to drug ordering and use of a reliable dosing guideline is highly recommended.

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APA: Copy

FAHIMI, FANAK, EMAMI, SEPIDEH, & RASHID FAROKHI, FARIN. (2012). THE RATE OF ANTIBIOTIC DOSAGE ADJUSTMENT IN RENAL DYSFUNCTION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 157-161. SID. https://sid.ir/paper/287906/en

Vancouver: Copy

FAHIMI FANAK, EMAMI SEPIDEH, RASHID FAROKHI FARIN. THE RATE OF ANTIBIOTIC DOSAGE ADJUSTMENT IN RENAL DYSFUNCTION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):157-161. Available from: https://sid.ir/paper/287906/en

IEEE: Copy

FANAK FAHIMI, SEPIDEH EMAMI, and FARIN RASHID FAROKHI, “THE RATE OF ANTIBIOTIC DOSAGE ADJUSTMENT IN RENAL DYSFUNCTION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 157–161, 2012, [Online]. Available: https://sid.ir/paper/287906/en

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