NITRIC OXIDE IS NECESSARY FOR DIAZOXIDE PROTECTION AGAINST ISCHEMIC INJURY IN SKELETAL MUSCLE

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FARAHINI HOSSEIN; AJAMI MARJAN; MIRZAY RAZAZ JALALEDIN; AZAD NAHID; SOLEIMANI MANSOOREH; AYATOLLAHI SEYYED ABDULMAJID; ABOTALEB NAHID; PEYROVIE HABIBOLAH; PAZOKI TOROUDI HAMIDREZA

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Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:1 Page(s): 375-381

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NITRIC OXIDE IS NECESSARY FOR DIAZOXIDE PROTECTION AGAINST ISCHEMIC INJURY IN SKELETAL MUSCLE

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Abstract

Ischemia reperfusion injury (IR injury) is a common problem in clinical conditions. Researches have frequently revealed that ATP- sensitive potassium (KATP) channels and nitric oxide plays a role in protection against ischemic injury in skeletal muscle. The present study aimed at evaluating the possible link between this two pathways.Sixty-eight male wistar rats, were pretreated with saline, diazoxide (KATP opener; 45 mg/Kg, IP), glibenclamide (KATP inhibitor; 5 mg/Kg), or L-NAME (iNOS inhibitor; 20 mg/Kg, IP) before 3 h ischemia and 2 h reperfusion. Activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and the level of malondialdehyde (MDA) and expression of iNOS were measured in muscle tissue.Tissue MDA content was significantly increased by IR (p<0.001). Diazoxide significantly decreased the IR-induced elevation of tissue MDA level (p<0.05) and Glibenclamide increased MDA (p<0.05 vs. IR group). L-NAME inhibited the effect of diazoxide on decreasing MDA (p<0.01 vs., diazoxide +IR group) and IR decreased the activity of SOD and CAT (p<0.01), while pretreatment with diazoxide increased activity of SOD and CAT (p<0.01). Glibenclamide decreased SOD and CAT activity after IR (p<0.05). L-NAME pretreatmentin diazoxide-treated rats abolished the effect of diazoxide on increasing the activity of SOD and CAT (p<0.05 vs. Diaz +IR). Expression of iNOS was increased by IR (p<0.01 vs. Sham group). Diazoxide significantly decreased iNOS expression after IR (p<0.05 vs. IR). L-NAME significantly decreased iNOS expression after IR (p<0.01) in diazoxide-treated rats (p<0.01 vs. Diaz +IR).

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APA: Copy

FARAHINI, HOSSEIN, AJAMI, MARJAN, MIRZAY RAZAZ, JALALEDIN, AZAD, NAHID, SOLEIMANI, MANSOOREH, AYATOLLAHI, SEYYED ABDULMAJID, ABOTALEB, NAHID, PEYROVIE, HABIBOLAH, & PAZOKI TOROUDI, HAMIDREZA. (2012). NITRIC OXIDE IS NECESSARY FOR DIAZOXIDE PROTECTION AGAINST ISCHEMIC INJURY IN SKELETAL MUSCLE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(1), 375-381. SID. https://sid.ir/paper/287934/en

Vancouver: Copy

FARAHINI HOSSEIN, AJAMI MARJAN, MIRZAY RAZAZ JALALEDIN, AZAD NAHID, SOLEIMANI MANSOOREH, AYATOLLAHI SEYYED ABDULMAJID, ABOTALEB NAHID, PEYROVIE HABIBOLAH, PAZOKI TOROUDI HAMIDREZA. NITRIC OXIDE IS NECESSARY FOR DIAZOXIDE PROTECTION AGAINST ISCHEMIC INJURY IN SKELETAL MUSCLE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(1):375-381. Available from: https://sid.ir/paper/287934/en

IEEE: Copy

HOSSEIN FARAHINI, MARJAN AJAMI, JALALEDIN MIRZAY RAZAZ, NAHID AZAD, MANSOOREH SOLEIMANI, SEYYED ABDULMAJID AYATOLLAHI, NAHID ABOTALEB, HABIBOLAH PEYROVIE, and HAMIDREZA PAZOKI TOROUDI, “NITRIC OXIDE IS NECESSARY FOR DIAZOXIDE PROTECTION AGAINST ISCHEMIC INJURY IN SKELETAL MUSCLE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 1, pp. 375–381, 2012, [Online]. Available: https://sid.ir/paper/287934/en

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