PROTECTIVE EFFECT OF LEAVES OF MURRAYA KOENIGII ON RESERPINE-INDUCED OROFACIAL DYSKINESIA

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PATIL RUPALI; DHAWALE KIRAN; GOUND HANMANT; GADAKH RAJENDRA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2012 | Volume:11 | Issue:2 Page(s): 635-641

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Title

PROTECTIVE EFFECT OF LEAVES OF MURRAYA KOENIGII ON RESERPINE-INDUCED OROFACIAL DYSKINESIA

Author(s)

PATIL RUPALI | DHAWALE KIRAN | GOUND HANMANT | GADAKH RAJENDRA | Issue Writer Certificate

Keywords

VACUOUS CHEWING MOVEMENTS

TONGUE PROTRUSIONS

FREE RADICALS

MURRAYA KOENIGII

Abstract

Murraya koenigii L. (Rutaceae), commonly known as curry leaf tree, closely associated with south India where the word "curry" originates from the Tamil "kari" for spiced sauces. Curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. Curry leaf has a potential role in the treatment of diabetes. Reserpine-induced orofacial dyskinesia in rats is an animal model of tardive dyskinesia that has been linked with free radical generation and oxidative stress. In this study, neuroprotective potential and in-vivo antioxidant status of methanol extract of the leaves of MURRAYA KOENIGII (MEMK) in reserpine-induced orofacial dyskinesia are investigated. Reserpine was used to induce orofacial dyskinesia. The effect of MEMK on locomotion and catalepsy was studied using Open-field apparatus and Bar-test, respectively. The effect of MEMK on the levels of protective anti-oxidant enzymes i.e. superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH) and inhibited lipid peroxidation (LPO) in forebrain region were investigated in reserpine-treated animals. Results demonstrated that the MEMK significantly inhibited the reserpine-induced VACUOUS CHEWING MOVEMENTS (VCM), tongue protrusion (TP), orofacial burst (OB) and catalepsy. MEMK significantly increased the number of squares traversed and rearing in open field apparatus. Treatment with MEMK significantly restored the levels of protective anti-oxidant enzymes i.e. SOD, CAT, GSH and inhibited LPO in forebrain region when compared with reserpine. It also inhibited haloperidol-induced catalepsy. The present study concludes that the oxidative stress might play an important role in reserpine-induced abnormal oral movements, and MURRAYA KOENIGII may have great potential in the treatment of neuroleptic-induced orofacial dyskinesia.

Cites

ANTIDEPRESSANT-LIKE EFFECT OF LAVANDULA ANGUSTIFOLIA MILL AND CITRUS AURANTIUM DUH ESSENTIAL OILS WITH FORCED SWIMMING TEST IN RESERPINIZED MICE BALB/C

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APA: Copy

PATIL, RUPALI, DHAWALE, KIRAN, GOUND, HANMANT, & GADAKH, RAJENDRA. (2012). PROTECTIVE EFFECT OF LEAVES OF MURRAYA KOENIGII ON RESERPINE-INDUCED OROFACIAL DYSKINESIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 11(2), 635-641. SID. https://sid.ir/paper/287945/en

Vancouver: Copy

PATIL RUPALI, DHAWALE KIRAN, GOUND HANMANT, GADAKH RAJENDRA. PROTECTIVE EFFECT OF LEAVES OF MURRAYA KOENIGII ON RESERPINE-INDUCED OROFACIAL DYSKINESIA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2012;11(2):635-641. Available from: https://sid.ir/paper/287945/en

IEEE: Copy

RUPALI PATIL, KIRAN DHAWALE, HANMANT GOUND, and RAJENDRA GADAKH, “PROTECTIVE EFFECT OF LEAVES OF MURRAYA KOENIGII ON RESERPINE-INDUCED OROFACIAL DYSKINESIA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 11, no. 2, pp. 635–641, 2012, [Online]. Available: https://sid.ir/paper/287945/en

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